Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1381
Phthalic Acids
male gamete generation
decrease
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Mus musculus
Phthalate mixtures adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.
33711355
1382
Polychlorinated Biphenyls
male gamete generation
affect
male meiosis chromosome separation
GO:0051308
Homo sapiens
Polychlorinated Biphenyls affects male meiosis chromosome separation
26535963
1383
Polychlorinated Dibenzodioxins
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Polychlorinated Dibenzodioxins results in decreased spermatogenesis
27713107
1384
Progestins
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Progestins co-treated with Testosterone analog] results in decreased spermatogenesis
3297020
1385
Progestins
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Progestins co-treated with Testosterone] results in decreased spermatogenesis
15572414
1386
Progestins
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Testosterone co-treated with Progestins] results in decreased spermatogenesis
16318399
1387
Prostaglandin D2
male gamete generation
affect
male germ-line stem cell asymmetric division
GO:0048133
Mus musculus
Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis
25142465
1388
quinalphos
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
quinalphos affects spermatogenesis
34014595
1389
quinalphos
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
[quinalphos affects spermatogenesis] which affects sperm head
34014595
1390
Quinoline Derivative?
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Quinoline derivative enhances human sperm motility and improves the functional competence
33237520
1391
resmethrin
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
resmethrin results in decreased spermatogenesis
31593228
1392
Resveratrol
male gamete generation
affect
spermatogonial stem cells (SSCs) activity
N/A
Mus musculus
Resveratrol changes spermatogonial stem cells activity and ameliorates their loss in busulfan-induced infertile mouse.
27806317
1393
Retinoic acid
male gamete generation
increase
spermatogenesis
GO:0007283
Mus musculus
Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production
25519186
1394
Retinoic acid
male gamete generation
affect
spermatogonial cell division
GO:0007284
Mus musculus
Retinoic acid availability drives the asynchronous initiation of spermatogonial differentiation in the mouse.
20650878?
1395
Ritonavir
male gamete generation
decrease
Sperm capacitation
GO:0048240
Mus musculus
Ritonavir may have negative effects on sperm function through an abnormal increase in tyrosine phosphorylation and phospho-AKT levels.
36198369
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
