Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1Indolactam Vembryo developmentaffectESC differentiationN/AMus musculusthe effects of (-) Indolactam V on a population of mouse ESCs (mESCs) that had been induced to form definitive endoderm (DE)19287398, 19896224
2Indolactam Vembryo developmentaffectESC differentiationN/AHomo sapiensHigh-content chemical screening identified a small molecule, (?)-indolactam V, that induces differentiation of a substantial number of Pdx1-expressing cells from human ESCs19287398, 19896224
313-cis-retinoic acidembryo developmentdecreasemesoderm formationGO:0001707Homo sapiensDisruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid30154523
41-Methyladenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
51-Methylhistidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
61-Methylnicotinamideembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
72,2',4,4'-tetrabromodiphenyl etherembryo developmentincreaseDNA methylation involved in embryo developmentGO:0043045Homo sapiens[[Environmental Pollutants results in increased abundance of Halogenated Diphenyl Ethers] which results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which affects DNA methylation involved in embryo development32653021
82,4-diaminobuturic acidembryo developmentdecreaseembryo developmentGO:0009790Mus musculus2,4-diaminobuturic acid at a low concentration irreversibly damaged the trophoblast cells and prevented outgrowth, probably due to nonsaturation kinetics resulting in a high intracellular accumulation.525368
92,6DQTembryo developmentincreaseblastocyst developmentGO:0001824Mus musculusIn vitro fertilization (IVF) experiments using Swiss albino mice revealed that spermatozoa processed with 2,6DQT resulted in significantly lower blastocyst rate (P < 0.05) compared to control. (2,6DQT ((4-((2,6-Dichloroquinolin-3-yl)methyl)- 2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one)) 33237520
102-Aminoadipateembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
112-chloro-5-nitrobenzanilideembryo developmentdecreasecell differentiation involved in embryonic placenta developmentGO:0060706Homo sapiens2-chloro-5-nitrobenzanilide results in decreased cell differentiation involved in embryonic placenta development30810372
122'-Deoxyadenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
132'-Deoxyadenosineembryo developmentdecreaseembryo developmentGO:0009790Mus musculusIf sperm were treated by both pentoxifylline and 2-deoxyadenosine before insemination of postovulatory mouse oocytes, two-cell embryo formation was found to be reduced even if both agents were eluted from the sperm before insemination. 8062965
142'-Deoxycytidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
152'-Deoxycytidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276

Showing 1 to 15 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.