Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1351
n-3 PUFA
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
n-3 PUFA (Fatty Acids, Omega-3) inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which affects spermatogenesis]
33068716
1352
Nicotine
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
Nicotine results in decreased spermatid development
30896085
1353
Nicotine
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
royal jelly inhibits the reaction [Nicotine results in decreased spermatid development]
30896085
1354
nitric oxide
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Higher concentration of NO reduced sperm cell function, while lower concentration of NO donors enhanced sperm motion and viability.
11369599, 7615122, 8582980
1355
Nitric Oxide
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Nitric Oxide results in decreased spermatogenesis
29983398
1356
Nitrites
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Nitrites results in decreased spermatogenesis
29983398
1357
Norethindrone
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Norethindrone co-treated with Testosterone] results in decreased spermatogenesis
15535423
1358
novaluron
male gamete generation
decrease
Sperm capacitation
GO:0048240
Mus musculus
Novaluron Has Detrimental Effects on Sperm Functions
35010320
1359
Paraquat
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Paraquat results in decreased spermatogenesis
31911963
1360
Paraquat
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
crocin inhibits the reaction [Paraquat results in decreased spermatogenesis]
31911963
1361
Parathion
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
[Parathion results in decreased abundance of Testosterone] which affects spermatogenesis
17375462
1362
Particulate Matter
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
Particulate Matter results in decreased spermatid development
29165613
1363
Particulate Matter
male gamete generation
decrease
spermatocyte division
GO:0048137
Mus musculus
Particulate Matter results in decreased spermatocyte division
29165613
1364
pentoxifylline
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement.
33237520, 7890078, 9513848
1365
pentoxifylline
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Both biotin and pentoxifylline supplementation resulted in significant increase in total motility (p < 0.05), progressive motility (p < 0.001) and rapid progressive motility (p < 0.05 v/s biotin and p < 0.01 v/s pentoxifylline) compared to the control at 1 h post-incubation period.
22527895, 12031048, 8530658
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
