Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1366perfluorooctane sulfonic acidmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusperfluorooctane sulfonic acid results in decreased spermatogenesis27818224
1367perfluorooctane sulfonic acidmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusperfluorooctane sulfonic acid results in decreased spermatogenesis33359577
1368perfluorooctanoic acidmale gamete generationdecreasespermatid developmentGO:0007286Homo sapiensPerfluorooctanoic acid results in decreased spermatid development31841032
1369Pesticidesmale gamete generationdecreasespermatogenesisGO:0007283Homo sapiens[PON1 protein polymorphism results in increased susceptibility to Pesticides] which results in decreased spermatogenesis18430447
1370phenolmale gamete generationincreasespermatocytes chromosomal aberrations N/AMus musculusPhenol has been evaluated for genotoxicity in both in vivo and in vitro test systems. Increased chromosomal aberrations have been reported in bone marrow and in spermatocytes from mice treated with phenol.24416599
1371phenol-hydroquinonemale gamete generationdecreasepositive regulation of flagellated sperm motility involved in capacitationGO:0060474Homo sapiensExposure to phenol-hydroquinone caused a significant decline in both, sperm motility and viability. Exposure to a phenol-hydroquinone (Phase I) microenvironment may therefore inhibit metabolically active enzymes, thus impeding ATP production, and in turn lowers sperm motility and viability. 24416599
1372phenylhydrazinemale gamete generationdecreasespermatid developmentGO:0007286Mus musculusphenylhydrazine results in decreased spermatid development30140404
1373phenylhydrazinemale gamete generationdecreasespermatid developmentGO:0007286Mus musculusAscorbic Acid inhibits the reaction [phenylhydrazine results in decreased spermatid development]30140404
1374phenylhydrazinemale gamete generationincreasesperm DNA condensationGO:0035092Mus musculusphenylhydrazine results in increased sperm DNA condensation30140404
1375phenylhydrazinemale gamete generationincreasesperm DNA condensationGO:0035092Mus musculusAscorbic Acid inhibits the reaction [phenylhydrazine results in increased sperm DNA condensation]30140404
1376phenylhydrazinemale gamete generationincreasespermatogenesisGO:0007283Mus musculusroyal jelly inhibits the reaction [phenylhydrazine results in decreased spermatogenesis]35099105
1377phenylhydrazinemale gamete generationincreasespermatogenesisGO:0007283Mus musculusphenylhydrazine results in decreased spermatogenesis35099105
1378phenylhydrazinemale gamete generationincreasesperm DNA condensationGO:0035092Mus musculusroyal jelly inhibits the reaction [phenylhydrazine results in decreased sperm DNA condensation]35099105
1379phenylhydrazinemale gamete generationincreasesperm DNA condensationGO:0035092Mus musculusphenylhydrazine results in decreased sperm DNA condensation35099105
1380Phthalic Acidsmale gamete generationdecreasesperm capacitationGO:0048240Mus musculusPhthalate mixtures adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development. 33711355

Showing 1366 to 1380 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.