Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1396
Rosmarinic acid
male gamete generation
increase
negative regulation of sperm capacitation
GO:1902491
Homo sapiens
Rosmarinic acid results in increased negative regulation of sperm capacitation
30009954
1397
Royal jelly
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
royal jelly inhibits the reaction [Nicotine results in decreased spermatid development]
30896085
1398
Royal jelly
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
royal jelly inhibits the reaction [phenylhydrazine results in decreased spermatogenesis]
35099105
1399
Royal jelly
male gamete generation
decrease
sperm DNA condensation
GO:0035092
Mus musculus
royal jelly inhibits the reaction [phenylhydrazine results in decreased sperm DNA condensation]
35099105
1400
Sildenafil citrate
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
In vitro studies of sildenafil citrate demonstrate a stimulatory effect on sperm motility with an increase in intracellular cAMP.
18087651, 33663030
1401
Rapamycin
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Sirolimus results in decreased spermatogenesis
17845575
1402
Sodium arsenate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
sodium arsenate results in decreased spermatogenesis
29040955
1403
Sodium arsenate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
epigallocatechin gallate inhibits the reaction [sodium arsenate results in decreased spermatogenesis]
29040955
1404
Sodium arsenate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Sulfur Dioxide co-treated with sodium arsenite] results in decreased spermatogenesis
30195209
1405
Sodium arsenate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
sodium arsenite results in decreased spermatogenesis
32991915
1406
Sodium arsenate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased spermatogenesis]
33242462
1407
Sodium fluoride
male gamete generation
decrease
sperm capacitation
GO:0048240
Mus musculus
Short-term exposure of spermatozoa to NaF significantly reduced the intracellular calcium concentration, protein kinase-A activity, and tyrosine phosphorylation of sperm proteins, which were associated with a significant decrease in the rate of capacitation and the acrosome reaction.
25854509
1408
Sodium glutamate
male gamete generation
decrease
primary spermatocyte growth
GO:0007285
Mus musculus
[Sodium Glutamate affects seminiferous tubule development] which results in decreased primary spermatocyte growth
24502529
1409
Sodium glutamate
male gamete generation
increase
spermatogenesis
GO:0007283
Mus musculus
Sodium Glutamate results in increased spermatogenesis
24502529
1410
Sodium nitroprusside
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Sodium nitroprusside suppresses male fertility in vitro.
25180787
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
