Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1321Lysophosphatidylcholine (PC 16:0/22:6)male gamete generationrelatespermatogenesisGO:0007283Homo sapiensRatio of LPC 16:0 to PC 16:0/22:6 and ratio of LPC 22:6 to PC 16:0/22:6 Increased in sperm with damaged membrane structure.34445473, 12472619
1322Malathionmale gamete generationdecreasespermatogenesisGO:0007283Mus musculuslavender oil inhibits the reaction [Malathion results in decreased spermatogenesis]30409133
1323Malathionmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusMalathion results in decreased spermatogenesis30409133
1324Malathionmale gamete generationdecreasespermatid developmentGO:0007286Mus musculuslavender oil inhibits the reaction [Malathion results in decreased spermatid development]30409133
1325Malathionmale gamete generationdecreasespermatid developmentGO:0007286Mus musculusMalathion results in decreased spermatid development30409133
1326Mancozebmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusmancozeb results in decreased spermatogenesis30037311
1327Manganesemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[manganese chloride results in increased abundance of Manganese] which results in decreased spermatogenesis32445656
1328Manganesemale gamete generationaffectspermatogenesisGO:0007283Mus musculus[manganese chloride results in increased abundance of Manganese] which affects spermatogenesis34822792
1329Manganesemale gamete generationaffectspermatogenesisGO:0007283Mus musculusYTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which affects spermatogenesis]34822792
1330Manganese chloridemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[manganese chloride results in increased abundance of Manganese] which results in decreased spermatogenesis32445656
1331Manganese chloridemale gamete generationaffectspermatogenesisGO:0007283Mus musculus[manganese chloride results in increased abundance of Manganese] which affects spermatogenesis34822792
1332Manganese chloridemale gamete generationaffectspermatogenesisGO:0007283Mus musculusYTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which affects spermatogenesis]34822792
1333Matrinemale gamete generationaffectpositive regulation of sperm capacitationGO:1902492Mus musculusmatrine results in decreased positive regulation of sperm capacitation26867864
1334Medroxyprogesteronemale gamete generationdecreasespermatogenesisGO:0007283Homo sapiens[Medroxyprogesterone co-treated with Testosterone] results in decreased spermatogenesis15535423
1335Medroxyprogesterone Acetatemale gamete generationdecreasespermatogenesisGO:0007283Homo sapiens[Testosterone co-treated with Medroxyprogesterone Acetate] results in decreased spermatogenesis18438174

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.