Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1306
lead acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
lead acetate results in decreased spermatogenesis
22806249
1307
lead acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis
32142724
1308
lead acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis
32142724
1309
lead acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis
34508822
1310
lead acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis]
34508822
1311
lead chloride
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
[lead chloride results in increased abundance of Lead] which affects spermatogenesis
31647946
1312
Levonorgestrel
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Levonorgestrel co-treated with testosterone enanthate] results in decreased spermatogenesis
11020511
1313
Levonorgestrel
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[testosterone undecanoate co-treated with Levonorgestrel] results in decreased spermatogenesis
10931079|17504903
1314
Levonorgestrel
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[testosterone enanthate co-treated with Levonorgestrel] results in decreased spermatogenesis
15867009
1315
Levonorgestrel
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Levonorgestrel promotes the reaction [testosterone enanthate results in decreased spermatogenesis]
10386821
1316
Levonorgestrel
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Levonorgestrel co-treated with Testosterone] results in decreased spermatogenesis
15535423
1317
Linoleic acid
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Linoleic acid was effective at stimulating ROS generation by human spermatozoa. This effect was observed in the absence of any significant impact on sperm viability, with the exception of the highest dose tested
16895947
1318
Lysophosphatidic acid
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
LPA significantly improved the motility parameters of human sperm hyperactivation in a dose-dependent manner. The LPA-induced elevation of sperm motility is dependent on bovine serum albumin (BSA) but independent of the classical BSA-induced sAC/cAMP/PKA signaling pathway.?
35903269?
1319
Lysophosphatidylcholine (LPC 16:0)
male gamete generation
relate
spermatogenesis
GO:0007283
Homo sapiens
Ratio of LPC 16:0 to PC 16:0/22:6 Increased in sperm with damaged membrane structure.
34445473, 12472619
1320
Lysophosphatidylcholine (LPC 22:6)
male gamete generation
relate
spermatogenesis
GO:0007283
Homo sapiens
Ratio of LPC 22:6 to PC 16:0/22:6 increased in sperm with damaged membrane structure.
34445473, 12472619
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
