Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1291
Hypotaurine?
male gamete generation
increase
sperm DNA condensation
GO:0035092
Homo sapiens
Hypotaurine supplementation limited cryo-capacitation, increased the proportion of live and progressively motile spermatozoa and reduces the percentage of spermatozoa showing chromatin decondensation, DNA fragmentation and nuclear vacuolation.
34732137, 23760160
1292
Icariin
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis]
31175881
1293
Lanthanum oxide
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
lanthanum oxide results in decreased spermatogenesis
32741894
1294
Lavender oil
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
lavender oil inhibits the reaction [Malathion results in decreased spermatogenesis]
30409133
1295
Lavender oil
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
lavender oil inhibits the reaction [Malathion results in decreased spermatid development]
30409133
1296
L-Carnitine
male gamete generation
increase
sperm capacitation
GO:0048240
Homo sapiens
L-Carnitine (LC), present in the epididymal fluid, support sperm motility, maturation and fertilization, and protect against oxidative damage by reducing apoptosis
29136144, 480318, 15193480, 16152768
1297
L-Carnitine
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
L-Carnitine (LC), present in the epididymal fluid, support sperm motility, maturation and fertilization, and protect against oxidative damage by reducing apoptosis
29136144, 480318, 15193480, 16152768
1298
Lead
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
[lead chloride results in increased abundance of Lead] which affects spermatogenesis
31647946
1299
Lead
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis
32142724
1300
Lead
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis
32142724
1301
Lead
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis
34508822
1302
Lead
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis]
34508822
1303
Lead
male gamete generation
affect
DNA methylation involved in gamete generation
GO:0043046
Homo sapiens
Lead affects DNA methylation involved in gamete generation
26417717
1304
Lead
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Lead results in decreased spermatogenesis
32976933
1305
lead acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
lead acetate results in decreased spermatogenesis
22806249
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
