Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1276
Flutamide
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Flutamide results in decreased spermatogenesis
14585929
1277
fumonisin B1
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
fumonisin B1 affects spermatogenesis
35697133
1278
furosemide
male gamete generation
decrease
sperm capacitation
GO:0048240
Mus musculus
bumetanide and furosemide, two blockers of Na(+)/K(+)/Cl(-) cotransporters (NKCC), inhibited all capacitation-associated events, suggesting that these transporters may mediate Cl(-) movements in sperm.
18957426
1279
Gallic Acid
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis]
35196152
1280
gamma-aminobutyric acid
male gamete generation
affect
sperm capacitation
GO:0048240
Mus musculus
Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration. GABA facilitated the tyrosine phosphorylation of sperm proteins, which is an index of sperm capacitation.
31178551
1281
genistein
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
Genistein and mono(2-ethylhexyl) phthalate (MEHP)? disrupt the eicosanoid pathway in Spermatogonial Stem Cells.