Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1276Flutamidemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusFlutamide results in decreased spermatogenesis14585929
1277fumonisin B1male gamete generationaffectspermatogenesisGO:0007283Mus musculusfumonisin B1 affects spermatogenesis35697133
1278furosemidemale gamete generationdecreasesperm capacitationGO:0048240Mus musculusbumetanide and furosemide, two blockers of Na(+)/K(+)/Cl(-) cotransporters (NKCC), inhibited all capacitation-associated events, suggesting that these transporters may mediate Cl(-) movements in sperm. 18957426
1279Gallic Acidmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusGallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis]35196152
1280gamma-aminobutyric acidmale gamete generationaffectsperm capacitationGO:0048240Mus musculusCapacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration. GABA facilitated the tyrosine phosphorylation of sperm proteins, which is an index of sperm capacitation. 31178551
1281genisteinmale gamete generationaffectspermatogenesisGO:0007283Mus musculusGenistein and mono(2-ethylhexyl) phthalate (MEHP)? disrupt the eicosanoid pathway in Spermatogonial Stem Cells.34942354
1282genisteinmale gamete generationaffectspermatogenesisGO:0007283Mus musculusGenistein and mono(2-ethylhexyl) phthalate (MEHP) increase Spermatogonial Stem Cell differentiation markers.34942354
1283genisteinmale gamete generationaffectspermatogenesisGO:0007283Mus musculusGenistein and mono(2-ethylhexyl) phthalate (MEHP) may affect Spermatogonial Stem Cell differentiation by altering eicosanoids.34942354
1284Gingerolmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusGingerol inhibits the reaction [Dextran Sulfate results in decreased spermatogenesis]28421826
1285Ginsenoside Rg1male gamete generationdecreasespermatogenesisGO:0007283Mus musculusGinsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased spermatogenesis]33331133
1286glycidamidemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusglycidamide results in decreased spermatogenesis35032568
1287glyphosatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusglyphosate results in decreased spermatogenesis29908847
1288glyphosatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusglyphosate results in decreased spermatogenesis30785197
1289Hydrogen Sulfidemale gamete generationaffectspermatogenesisGO:0007283Mus musculusFatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which affects spermatogenesis]33068716
1290Hydrogen Sulfidemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased spermatogenesis33068716

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.