Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1141
Bisphenol A
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
bisphenol A results in decreased spermatogenesis
22951085
1142
Bisphenol A
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
bisphenol A results in decreased spermatogenesis
29741722
1143
Bisphenol A
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
[bisphenol A co-treated with Stigmasterol] results in decreased spermatid development
30245210
1144
Bisphenol A
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased spermatid development]
30245210
1145
Bisphenol A
male gamete generation
decrease
spermatocyte division
GO:0048137
Mus musculus
[bisphenol A co-treated with Stigmasterol] results in decreased spermatocyte division
30245210
1146
Bisphenol A
male gamete generation
decrease
spermatocyte division
GO:0048137
Mus musculus
NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased spermatocyte division]
30245210
1147
Bisphenol A
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
bisphenol A results in decreased spermatogenesis
32956838
1148
Bisphenol A
male gamete generation
affect
DNA methylation involved in gamete generation
GO:0043046
Homo sapiens
Bisphenol A affects DNA methylation involved in gamete generation
28582417
1149
Bisphenol A
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
Bisphenol A impairs mature sperm functions by a catSper-relevant mechanism.
27125968
1150
Bisphenol A diglycidyl ether (BADGE)
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function.
32508751
1151
Bisphenol AF (BPAF)
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function.
32508751, 32954995
1152
Bisphenol B(BPB)
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function.
32508751, 32954995
1153
Bisphenol BP (BPBP)
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function.
32508751, 32954995
1154
Bisphenol C (BPC)
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function.
32508751, 32954995
1155
Bisphenol G (BPG)
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function.
32508751, 32954995
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
