Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1111
Adjudin
male gamete generation
affect
sperm capacitation
GO:0048240
Homo sapiens
Adjudin is a potent blocker of Cl? channels: disrupting Cl? ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro
23117128
1112
Aflatoxin B1
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Aflatoxin B1 results in decreased spermatogenesis
29274131
1113
Aflatoxin B1
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
Aflatoxin B1 results in decreased spermatid development
30126036
1114
Alpha lipoic acid
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Mus musculus
Mouse sperm incubation with different doses of Alpha lipoic acid affect motility.
36640903
1115
Vitamin E
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
alpha-Tocopherol (Vitamin E) inhibits the reaction [Methyl Parathion results in decreased spermatid development]
32294493
1116
Ammonium nitrate
male gamete generation
affect
sperm capacitation
GO:0048240
Mus musculus
ammonium nitrate induce detrimental effects on capacitation status.
32866586
1117
Ammonium nitrate
male gamete generation
decrease
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Mus musculus
ammonium nitrate adversely affects sperm motility and motion kinematics.
32866586
1118
Ammonium sulfate
male gamete generation
affect
sperm capacitation
GO:0048240
Mus musculus
ammonium sulfate induce detrimental effects on capacitation status.
32866586
1119
Ammonium sulfate
male gamete generation
decrease
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Mus musculus
ammonium sulfate adversely affects sperm motility and motion kinematics.
32866586
1120
Arachidonic acid
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Arachidonic acid (AA) induced a time- and dose-dependent increase in ROS generation by human spermatozoa that led to the promotion of peroxidative damage and a loss of sperm motility.
16895947
1121
Arsenic
male gamete generation
affect
spermatogenesis
GO:0007283
Homo sapiens
Arsenic affects spermatogenesis
22776062
1122
Arsenic Trioxide
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Arsenic Trioxide results in decreased spermatogenesis
28956719
1123
Arsenic Trioxide
male gamete generation
affect
spermatid development
GO:0007286
Mus musculus
Arsenic Trioxide affects spermatid development
32112876
1124
Arsenic Trioxide
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Arsenic Trioxide results in decreased spermatogenesis
18630931|32112876
1125
Ascorbic Acid
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased spermatid development]
30140404
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
