Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1171
Cadmium
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased spermatogenesis
32199951
1172
Cadmium
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Cadmium results in decreased spermatogenesis
32976933
1173
Cadmium Chloride
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased spermatogenesis
32199951
1174
Caffeine
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement.
33237520, 7890078, 9513849
1175
Calcimycin
male gamete generation
increase
positive regulation of sperm capacitation
GO:1902492
Homo sapiens
Calcimycin results in increased positive regulation of sperm capacitation
30009954
1176
Cannabidiol
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
Cannabidiol affects spermatogenesis
34774840
1177
Cannabidiol
male gamete generation
increase
acrosome assembly
GO:0001675
Mus musculus
Cannabidiol results in increased acrosome assembly
34774840
1178
Cannabinoids
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which results in decreased spermatogenesis
30521419
1179
Catechol
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Exposure of human sperm in vitro to varied concentrations of catechol caused only insignificant changes in sperm motility and viability as compared to those observed on exposure to phenol-hydroquinone. Hence, exposure to catechol appeared to have less toxic effects than those of phenol-hydroquinone.
24416599
1180
Cetrorelix
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[cetrorelix co-treated with testosterone enanthate] results in decreased spermatogenesis
18160741
1181
Cetrorelix
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased spermatogenesis
18160741
1182
Chlorambucil
male gamete generation
affect
male germ-line mutations
N/A
Mus musculus
Chlorambucil effectively induces deletion mutations in male mouse germ cells.
2726748, 2304907, 8552138
1183
Chlorambucil
male gamete generation
affect
male germ-line mutations
N/A
Mus musculus
High-frequency induction of chromosomal rearrangements in mouse germ cells by the chemotherapeutic agent chlorambucil.
8141802?
1184
Chlordecone
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
Chlordecone affects spermatogenesis
29980752
1185
Chlordecone
male gamete generation
affect
spermatogenesis
GO:0007283
Mus musculus
Chlordecone affects spermatogenesis
29980752
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
