Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1126Ascorbic Acidmale gamete generationdecreasesperm DNA condensationGO:0035092Mus musculusAscorbic Acid inhibits the reaction [phenylhydrazine results in increased sperm DNA condensation]30140404
1127Ascorbic Acidmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusAscorbic Acid inhibits the reaction [Dexamethasone results in decreased spermatogenesis]30526067
1128Ascorbic Acidmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusAscorbic Acid inhibits the reaction [Dexamethasone results in decreased spermatogenesis]30526067
1129Aspartamemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusAspartame results in decreased spermatogenesis32951320
1130Astaxanthinemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusastaxanthine results in increased spermatogenesis33132140
1131Atrazinemale gamete generationdecreasespermatocyte divisionGO:0048137Mus musculusAtrazine results in decreased spermatocyte division26518232
1132Atrazinemale gamete generationaffectspermatid developmentGO:0007286Mus musculusAtrazine affects spermatid development27655631
1133Atrazinemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusAtrazine results in decreased spermatogenesis27655631
1134Benzenemale gamete generationaffectsperm chromosomal aberrations N/AHomo sapiensMen exposed to high levels of benzene are more likely to have an abnormal amount of chromosome in their sperm, which impacts fertility and fetal development.24416599
1135Butylbenzyl phthalatemale gamete generationdecreasesperm capacitationGO:0048240Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1136Butylbenzyl phthalatemale gamete generationdecreasepositive regulation of flagellated sperm motility involved in capacitationGO:0060474Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1137Bifenthrinmale gamete generationdecreasespermatogenesisGO:0007283Mus musculusbifenthrin results in decreased spermatogenesis32408700
1138Biotinmale gamete generationincreasepositive regulation of flagellated sperm motility involved in capacitationGO:0060474Homo sapiensSupplementation of biotin to sperm preparation medium increases the motility and longevity in cryopreserved human spermatozoa22527895
1139Biotinmale gamete generationincreasepositive regulation of flagellated sperm motility involved in capacitationGO:0060474Homo sapiensBiotin can enhance the sperm motility and prolong the survival of frozen-thawed semen samples which may have potential benefit in assisted reproductive technology field.22527895
1140bisphenol Smale gamete generationdecreasespermatogenesisGO:0007283Mus musculusbis(4-hydroxyphenyl)sulfone results in decreased spermatogenesis29741722

Showing 1126 to 1140 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.