Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1081
Strontium chloride
fertilization
increase
female pronucleus assembly
GO:0035038
Mus musculus
perfluorodecanoic acid inhibits the reaction [strontium chloride results in increased female pronucleus assembly]
34358620
1082
Tobacco Smoke Pollution
fertilization
decrease
fertilization
GO:0009566
Mus musculus
Tobacco Smoke Pollution results in decreased fertilization
27589885
1083
Tobacco Smoke Pollution
fertilization
decrease
positive regulation of acrosome reaction
GO:2000344
Mus musculus
Tobacco Smoke Pollution results in decreased positive regulation of acrosome reaction
27589885
1084
Vitamin D
fertilization
increase
acrosome reaction
GO:0007340
Homo sapiens
Vitamin D enhances sperm vitality and the acrosome reaction and reduces the content of triglyceride in spermatozoa, which effectively increases their fertilization ability in the female reproductive tract.
30618415, 19014363
1085
Butadiene diepoxide
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Dose-dependent reductions of tetraploid cells, round spermatids, and elongated spermatids were detected at 7, 21, and 28 d, respectively, reflecting cytotoxic damage on the differentiating spermatogonia compartment.
8614013
1086
1,25(OH)2D
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
1,25(OH)2D may enhance sperm motility by promoting the synthesis of ATP both through the cAMP/PKA pathway and the increase in intracellular calcium ions.
30618415
1087
1,3-butadiene
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Butadiene-induced cytotoxic effects on differentiating spermatogonia were shown by a concentration-dependent decrease of round spermatids occurring 21 days after chemical exposure, confirmed by a similar decrease of elongated spermatids measured in testes sampled 7 days later.
[Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which results in decreased spermatogenesis
30521419
1089
1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3)
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. 1,25(OH)2D3 effects on sperm motility and acrosin activity are VDR-mediated.
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
2 compounds (6MQT and 2,6DQT) exhibited significant beneficial effect on sperm motility enhancement. Both the compounds improved the sperm motility, and enhanced kinetic parameters. (6MQT ((4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one, 2,6DQT ((4-((2,6-Dichloroquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one))
33237520
1093
25-hydroxyvitamin D
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
25-hydroxyvitamin D deficiency results in decreased spermatogenesis
28655646
1094
2'-Deoxyadenosine
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement.
33237520, 7890078, 9513852
1095
3,5,6-trichloro-2-pyridinol
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
3,5,6-trichloro-2-pyridinol results in decreased spermatogenesis
15579410
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
