Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1051MelatoninfertilizationdecreasefertilizationGO:0009566Mus musculusMelatonin inhibits the reaction [Ethinyl Estradiol results in decreased fertilization]31931096
1052MetforminfertilizationnotfertilizationGO:0009566Mus musculusno significant differences in the rate of fertilization between the two groups with or without 10 36393869
1053NAADPfertilizationincreaseacrosome reactionGO:0007340Mus musculusNAADP results in increased acrosome reaction24451262
1054NAADPfertilizationincreaseacrosome reactionGO:0007340Mus musculus1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog affects the reaction [NAADP results in increased acrosome reaction]24451262
1055NAADPfertilizationincreaseacrosome reactionGO:0007340Mus musculusTPCN1 protein affects the reaction [NAADP results in increased acrosome reaction]24451262
1056NAADPfertilizationincreaseacrosome reactionGO:0007340Mus musculus2-aminoethoxydiphenyl borate inhibits the reaction [NAADP results in increased acrosome reaction]24451262
1057NAADPfertilizationincreaseacrosomal vesicle exocytosisGO:0060478Mus musculusNAADP results in increased acrosomal vesicle exocytosis24451262
1058N-Acetyl-L-CysteinefertilizationincreasefertilizationGO:0009566Mus musculusN-Acetyl-L-Cysteine (NAC), results in increased fertilization rates of mouse oocytes. The enhanced fertilization efficiency may be mediated by cysteine reducing disulphide bonds and inducing expansion in the zona pellucida (ZP) of mouse oocytes, with the morphological changes allowing for greater fertilizing ability/activity29136144, 25715791
1059oleic acidfertilizationdecreasefertilizationGO:0009566Mus musculusExogenous oleic acids inhibited fertilization of mouse embryosEffect of Fatty Acids on Fertilization and Development of Mouse Embryos In Vitro
1060palmitic acidsfertilizationdecreasefertilizationGO:0009566Mus musculusExogenous palmitic acids inhibited fertilization of mouse embryosEffect of Fatty Acids on Fertilization and Development of Mouse Embryos?In Vitro
1061pentoxifyllinefertilizationdecreasefertilizationGO:0009566Mus musculusIf PTX was not washed out, fertilization was reduced significantly, yet development of fertilized oocytes was unaffected. If insemination was performed in the presence of PTX both fertilization and development were impaired. 7844224
1062perfluorodecanoic acidfertilizationincreasefemale pronucleus assemblyGO:0035038Mus musculusperfluorodecanoic acid inhibits the reaction [strontium chloride results in increased female pronucleus assembly]34358620
1063phenylhydrazinefertilizationdecreasefertilizationGO:0009566Mus musculusroyal jelly inhibits the reaction [phenylhydrazine results in decreased fertilization]35099105
1064phenylhydrazinefertilizationdecreasefertilizationGO:0009566Mus musculusphenylhydrazine results in decreased fertilization35099105
1065Phthalic Acidsfertilizationdecreaseacrosome reactionGO:0007340Mus musculusPhthalate mixtures adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development. 33711355

Showing 1051 to 1065 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.