Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1066Polychlorinated Biphenylsfertilizationincreasenegative regulation of fertilizationGO:0060467Homo sapiensPolychlorinated Biphenyls results in increased negative regulation of fertilization27576526
1067Progesteronefertilizationincreasepositive regulation of acrosome reactionGO:2000344Mus musculusMatrines inhibits the reaction [Progesterone results in increased positive regulation of acrosome reaction]26867864
1068Progesteronefertilizationincreasepositive regulation of acrosome reactionGO:2000344Mus musculusProgesterone results in increased positive regulation of acrosome reaction26867864
1069Progesteronefertilizationincreaseacrosome reactionGO:0007340Homo sapiensProgesterone results in increased acrosome reaction32508751
1070Progesteronefertilizationincreasesperm entryGO:0035037Homo sapiens[Progesterone results in increased sperm motility] which results in increased sperm entry32508751
1071Rosmarinic acidfertilizationincreasenegative regulation of acrosome reactionGO:1902225Homo sapiensrosmarinic acid results in increased negative regulation of acrosome reaction30009954
1072Royal jellyfertilizationdecreasefertilizationGO:0009566Mus musculusroyal jelly inhibits the reaction [phenylhydrazine results in decreased fertilization]35099105
1073Silver Compoundsfertilizationincreasenegative regulation of fertilizationGO:0060467Mus musculusSilver Compounds results in increased negative regulation of fertilization29964317
1074Silver Compoundsfertilizationincreasenegative regulation of fertilizationGO:0060467Mus musculusacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of fertilization]29964317
1075Sodium fluoridefertilizationaffectacrosome reactionGO:0007340Mus musculusSodium fluoride adversely affects sperm motility, morphology, capacitation, and the acrosome reaction. 25854509
1076Sodium fluoridefertilizationdecreasefertilizationGO:0009566Mus musculusSodium fluoride significantly reduced the fertilization during early embryonic development.25854509
1077Sodium nitritefertilizationincreasenegative regulation of fertilizationGO:0060467Mus musculusSodium Nitrite results in increased negative regulation of fertilization31476334
1078Sodium nitroprussidefertilizationdecreasefertilizationGO:0009566Mus musculussodium nitroprusside significantly decreased the rates of fertilization during embryo development.25180787
1079Sphingosine-1-PhosphatefertilizationdecreasefertilizationGO:0009566Homo sapiensAddition of S1P to human oocyte culture medium significantly reduced fertilization rate although such treatment decreased embryo fragmentation.20093086
1080Strontium chloridefertilizationincreasefemale pronucleus assemblyGO:0035038Mus musculusstrontium chloride results in increased female pronucleus assembly34358620

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.