Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1036
gamma-aminobutyric acid
fertilization
affect
acrosome reaction
GO:0007340
Mus musculus
GABA facilitated the tyrosine phosphorylation of sperm proteins, which is an index of sperm capacitation. GABA also promoted the acrosome reaction, which was suppressed by a selective GABA A receptor antagonist.
31178551
1037
Glutathione
fertilization
increase
fertilization
GO:0009566
Mus musculus
Exposure of oocytes to reduced glutathione (GSH) greatly improves the fertilization rate of frozen-thawed mouse sperm
25715791, 23916252
1038
Isoniazid
fertilization
decrease
fertilization
GO:0009566
Mus musculus
Isoniazid results in decreased fertilization
33771660
1039
Lavender oil
fertilization
increase
sperm DNA decondensation
GO:0035041
Mus musculus
lavender oil inhibits the reaction [Malathion results in increased sperm DNA decondensation]
30409133
1040
L-Carnitine
fertilization
increase
fertilization
GO:0009566
Homo sapiens
L-Carnitine (LC), present in the epididymal fluid, support sperm motility, maturation and fertilization, and protect against oxidative damage by reducing apoptosis
29136144, 480318, 15193480, 16152768
1041
Cysteine
fertilization
increase
fertilization
GO:0009566
Mus musculus
L-cysteine (L-Cys), D-cysteine (D-Cys) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo.
25715791
1042
Lysophosphatidic acid
fertilization
increase
fertilization
GO:0009566
Homo sapiens
Lysophosphatidic Acid is abundant in seminal plasma and follicular fluid. It improves oocyte fertilization.
35903269?
1043
Malathion
fertilization
increase
sperm DNA decondensation
GO:0035041
Mus musculus
lavender oil inhibits the reaction [Malathion results in increased sperm DNA decondensation]
30409133
1044
Malathion
fertilization
increase
sperm DNA decondensation
GO:0035041
Mus musculus
Malathion results in increased sperm DNA decondensation
30409133
1045
Matrines
fertilization
increase
positive regulation of acrosome reaction
GO:2000344
Mus musculus
Matrines inhibits the reaction [Progesterone results in increased positive regulation of acrosome reaction]
26867864
1046
Melatonin
fertilization
decrease
binding of sperm to zona pellucida
GO:0007339
Mus musculus
Melatonin inhibits the reaction [bisphenol A results in decreased binding of sperm to zona pellucida]
28178360
1047
Melatonin
fertilization
decrease
fertilization
GO:0009566
Mus musculus
Melatonin inhibits the reaction [bisphenol A results in decreased fertilization]
28178360
1048
Melatonin
fertilization
decrease
binding of sperm to zona pellucida
GO:0007339
Mus musculus
Melatonin inhibits the reaction [fenoxaprop ethyl results in decreased binding of sperm to zona pellucida]
31265864
1049
Melatonin
fertilization
decrease
binding of sperm to zona pellucida
GO:0007339
Mus musculus
Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased binding of sperm to zona pellucida]
31931096
1050
Melatonin
fertilization
decrease
binding of sperm to zona pellucida
GO:0007339
Mus musculus
Melatonin inhibits the reaction [[Ethinyl Estradiol results in increased cleavage of ZP2 protein] which results in decreased binding of sperm to zona pellucida]
31931096
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
