Chemicals with Transgenerational Effects on Disease or Function

Show
entries
No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1006CyclophosphamidefertilizationdecreasefertilizationGO:0009566Mus musculusCyclophosphamide results in decreased fertilization31557371
1007CyclophosphamidefertilizationdecreasefertilizationGO:0009566Mus musculuscoenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased fertilization]31557371
1008D-cysteinefertilizationincreasefertilizationGO:0009566Mus musculus L-cysteine (L-Cys), D-cysteine (D-Cys) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo. 25715791
1009Diethylhexyl phthalatefertilizationdecreaseacrosome reactionGO:0007340Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1010Dibutyl PhthalatefertilizationdecreasefertilizationGO:0009566Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization33711355
1011Dibutyl phthalatefertilizationdecreaseacrosome reactionGO:0007340Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1012Diethyl phthalatefertilizationdecreasefertilizationGO:0009566Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization33711355
1013Diethyl phthalatefertilizationdecreaseacrosome reactionGO:0007340Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1014Diethylhexyl phthalatefertilizationincreasenegative regulation of fertilizationGO:0060467Mus musculusDiethylhexyl Phthalate results in increased negative regulation of fertilization30649530
1015Diethylhexyl phthalatefertilizationdecreasefertilizationGO:0009566Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization33711355
1016Diisobutyl phthalatefertilizationdecreasefertilizationGO:0009566Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization33711355
1017Diisodecyl phthalatefertilizationincreasenegative regulation of fertilizationGO:0060467Mus musculusdiisononyl phthalate results in increased negative regulation of fertilization30649530
1018Diisodecyl phthalatefertilizationdecreasefertilizationGO:0009566Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization33711355
1019Diisodecyl phthalatefertilizationdecreasefertilizationGO:0009566Homo sapiensDiisodecyl phthalate results in decreased fertilization26545148
1020Diisodecyl phthalatefertilizationdecreasefertilizationGO:0009566Homo sapiensDiisononyl phthalate results in decreased fertilization26545148

Showing 1006 to 1020 of 1481 entries

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.