Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
976Zearalenonefemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusPD 0166285 inhibits the reaction [Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation]35504548
977Zearalenonefemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus[Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation] which affects Golgi organization35504548
978Zearalenonefemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus[Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation] which affects endoplasmic reticulum organization35504548
979Zearalenonefemale gamete generationincreaseDNA methylation involved in gamete generationGO:0043046Mus musculusThe fluorescence intensity analysis showed that the general DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice.?Mycotoxin-contaminated maize (deoxynivalenol (DON) at 3,875 24288346, 24810297
980Zearalenonefemale gamete generationincreaseoocyte maturationGO:0001556Mus musculusThe activation rate of maturated oocytes was affected in mice byzearalenone (ZEA) treatment, indicating that ZEA affects egg developmental competence.?25155023, 24810297
981Zincfemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Homo sapiens[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation26545973
982female gamete generationnotoocyte developmentGO:0048599Homo sapiensMetabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence23886995
9831-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acidfertilizationincreaseacrosome reactionGO:0007340Mus musculus1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog affects the reaction [NAADP results in increased acrosome reaction]24451262
9841-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acidfertilizationincreaseacrosome reactionGO:0007340Mus musculus1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog results in increased acrosome reaction24451262
9852,3',4,4',5-pentachlorobiphenylfertilizationincreasefertilizationGO:0009566Mus musculus2,3',4,4',5-pentachlorobiphenyl results in decreased fertilization31388691
9862-aminoethoxydiphenyl boratefertilizationincreaseacrosome reactionGO:0007340Mus musculus2-aminoethoxydiphenyl borate inhibits the reaction [NAADP results in increased acrosome reaction]24451262
9874(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl esterfertilizationdecreasesperm DNA decondensationGO:0035041Mus musculus4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester results in decreased sperm DNA decondensation29355596
9884,4'-hexafluorisopropylidene diphenolfertilizationincreaseacrosome reactionGO:0007340Homo sapiens4,4'-hexafluorisopropylidene diphenol results in increased acrosome reaction32508751
9894,4'-hexafluorisopropylidene diphenolfertilizationincreasesperm entryGO:0035037Homo sapiens[4,4'-hexafluorisopropylidene diphenol results in increased sperm motility] which results in increased sperm entry32508751
9904-phenylenediaminefertilizationincreasenegative regulation of fertilizationGO:0060467Mus musculus4-phenylenediamine results in increased negative regulation of fertilization35363429

Showing 976 to 990 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.