Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
991
Acetyl-aspartyl-glutamyl-valyl-aspartal
fertilization
increase
negative regulation of fertilization
GO:0060467
Mus musculus
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of fertilization]
29964317
992
Adjudin
fertilization
affect
fertilization
GO:0009566
Homo sapiens
Adjudin is a potent blocker of Cl? channels: disrupting Cl? ion transport function results in a decline in fertilizing ability in humans in vitro
23117128
993
Alprostadil
fertilization
increase
sperm entry
GO:0035037
Homo sapiens
[Alprostadil results in increased sperm motility] which results in increased sperm entry
32508751
994
Butylbenzyl phthalate
fertilization
decrease
acrosome reaction
GO:0007340
Mus musculus
An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.
33711355
995
Biotin
fertilization
increase
fertilization
GO:0009566
Mus musculus
Biotin group had significantly higher fertilization rate compared to control.
30284103
996
Bisphenol A
fertilization
decrease
acrosome reaction
GO:0007340
Mus musculus
bisphenol A results in decreased acrosome reaction
27125968
997
Bisphenol A
fertilization
decrease
binding of sperm to zona pellucida
GO:0007339
Mus musculus
bisphenol A results in decreased binding of sperm to zona pellucida
28178360
998
Bisphenol A
fertilization
decrease
binding of sperm to zona pellucida
GO:0007339
Mus musculus
Melatonin inhibits the reaction [bisphenol A results in decreased binding of sperm to zona pellucida]
28178360
999
Bisphenol A
fertilization
decrease
fertilization
GO:0009566
Mus musculus
Melatonin inhibits the reaction [bisphenol A results in decreased fertilization]
28178360
1000
Bisphenol A
fertilization
decrease
fertilization
GO:0009566
Mus musculus
bisphenol A results in decreased fertilization
25772901|28178360
1001
Butylbenzyl phthalate
fertilization
decrease
fertilization
GO:0009566
Mus musculus
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization
33711355
1002
Calcimycin
fertilization
increase
positive regulation of acrosome reaction
GO:2000344
Homo sapiens
Calcimycin results in increased positive regulation of acrosome reaction
30009954
1003
Cholesterol
fertilization
increase
egg activation
GO:0007343
Mus musculus
Excess cholesterol induces mouse egg activation and may cause female infertility
25368174
1004
Coenzyme Q11
fertilization
decrease
fertilization
GO:0009566
Mus musculus
coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased fertilization]
31557371
1005
Coenzyme Q12
fertilization
increase
fertilization
GO:0009566
Mus musculus
coenzyme Q10 results in increased fertilization
31557371
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
