Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
961
Testosterone
female gamete generation
relate
oogenesis
GO:0048477
Homo sapiens
Elevated follicular fluid androgen levels (testosterone) were associated with lower quality oocytes, and in particular with oocytes showing a trend toward lower cleavage rates after fertilization
4011065
962
Tetrachloroisophthalonitrile
female gamete generation
increase
primary follicle stage
GO:0048160
Mus musculus
tetrachloroisophthalonitrile results in increased primary follicle stage
30586609
963
Tetradecanedioic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
964
Thyroxine
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
965
Tricosanoic acid (C23:0)
female gamete generation
relate
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
966
Triglyceride
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
The mouse cumulus-oocyte complexes (COCs) exposed to lipid-rich follicular fluid during their maturation had increased oocyte lipid content, induction of endoplasmic reticulum stress markers, and impaired oocyte nuclear maturation.
22440252
967
Trizma acetate
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
968
Tryptophanol
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
969
Uridine
female gamete generation
affect
oogenesis
GO:0048477
Mus musculus
Uridine blocked 3H-adenosine uptake by oocyte-cumulus cell complexes (OCCs) and cumulus cell-enclosed oocytes (CEOs) by 82-85%
10331459
970
Uridine
female gamete generation
not
germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs)
N/A
Mus musculus
Uridine had no effect on germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) when meiotic arrest was maintained with hypoxanthine or hypoxanthine plus adenosine but reversed the combined inhibitory action of these purines in denuded oocytes (DOs).
10331459
971
Uridine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
972
Vitamin E
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Homo sapiens
[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation
26545973
973
Xanthosine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
974
Xanthurenic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
975
Zearalenone
female gamete generation
decrease
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation
35504548
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
