Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
946
Sorbitol
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
947
Spermidine
female gamete generation
decrease
oogenesis
GO:0048477
Mus musculus
SPD induces cytoprotective autophagy in FGSCs in vitro.
34099041
948
Spermine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
949
Sphingosine-1-Phosphate
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
Considering the blastulation rate together with the apoptotic event in the blastocysts, adding 100 and 500 nM S1P within oocyte maturation medium could be beneficial in the development of immature mouse oocytes.
21160167
950
Sphingosine-1-Phosphate
female gamete generation
increase
oogenesis
GO:0009790
Mus musculus
Considering the blastulation rate together with the apoptotic event in the blastocysts, adding 100 and 500 nM S1P within oocyte maturation medium could be beneficial in the development of immature mouse oocytes.
21160167
951
Sphingosine-1-Phosphate
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
Local application of sphingosine-1-phosphate protected ovarian follicles from chemotherapy-induced cell death.
16439991, 24336672
952
Stearic acid
female gamete generation
relate
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
953
Sterol 14
female gamete generation
not
oogenesis
GO:0048477
Mus musculus
Sterol 14
11133661, 11988327
954
Succinic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
955
Syringic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
956
T-2 Toxin
female gamete generation
decrease
oocyte maturation
GO:0001556
Mus musculus
T-2 Toxin results in decreased oocyte maturation
26138683
957
Taurine
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
958
Taurocholic Acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
959
Taxol
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
Taxol-induced meiotic maturation delay, spindle defects, and aneuploidy in mouse oocytes and zygotes.
10029682
960
Testosterone
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
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