Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
931
Guanosine
female gamete generation
affect
oogenesis
GO:0048477
Mus musculus
Guanosine metabolism by mouse oocytes: metabolic cooperativity between the fully grown oocyte and cumulus cells
7276886
932
Rotenone
female gamete generation
decrease
oocyte maturation
GO:0001556
Mus musculus
Percentages of MII oocytes decreased significantly with increasing concentrations of rotenone.
26857840
933
S-adenosylmethionine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
934
Selenium
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Homo sapiens
[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation
26545973
935
Silver Compounds
female gamete generation
increase
negative regulation of oocyte maturation
GO:1900194
Mus musculus
Silver Compounds results in increased negative regulation of oocyte maturation
29964317
936
Silver Compounds
female gamete generation
increase
negative regulation of oocyte maturation
GO:1900194
Mus musculus
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of oocyte maturation]
29964317
937
Small molecular compound 28 (C28)
female gamete generation
decrease
oogenesis
GO:0048477
Mus musculus
The number, viability, and proliferation of FGSCs were significantly reduced in C89-treated groups.
31216656
938
Small molecular compound 28 (C28)
female gamete generation
decrease
oogenesis
GO:0048477
Mus musculus
C28 can inhibit the proliferation and reduce?cell viability?of?FGSCs?in vitro by autophagy.
32949695
939
Small molecular compound 28 (C28)
female gamete generation
decrease
oogenesis
GO:0048477
Mus musculus
The expression of genes (Trib3,?DDIT3, and?ATF4) related to endoplasmic reticulum (ER) stress was enhanced by C28.
32949695
940
Small molecular compound 28 (C28)
female gamete generation
decrease
FGSCs autophagy
N/A
Mus musculus
C28 induced autophagy of FGSCs in vitro.
32949695
941
Small molecular compound 28 (C28)
female gamete generation
decrease
H3K27 acetylation
N/A
Mus musculus
The changes of histone H3K27 acetylation involves in C28 induced FGSCs autophagy.
31216656
942
Sodium butyrate
female gamete generation
decrease
oocyte maturation
GO:0001556
Mus musculus
A high concentration Sodium butyrate will impede the meiosis of oocytes
31356635
943
Sodium glutamate
female gamete generation
decrease
oocyte maturation
GO:0001556
Mus musculus
Sodium Glutamate results in decreased oocyte maturation
30733785
944
Sodium nitrite
female gamete generation
affect
egg coat formation
GO:0035803
Mus musculus
Sodium Nitrite affects egg coat formation
31476334
945
Sodium nitrite
female gamete generation
increase
negative regulation of oocyte maturation
GO:1900194
Mus musculus
Sodium Nitrite results in increased negative regulation of oocyte maturation
31476334
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
