Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
796Glyceraldehydefemale gamete generationrelatedoogenesisGO:0048477Mus musculusSignificantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
797Glycerophosphorylcholinefemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
798Glycinefemale gamete generationrelatedoogenesisGO:0048477Mus musculusSignificantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
799Glycocholic acidfemale gamete generationrelatedoogenesisGO:0048477Mus musculusSignificantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
800Glycolic acidfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
801glyphosatefemale gamete generationincreasenegative regulation of oocyte maturationGO:1900194Mus musculusglyphosate results in increased negative regulation of oocyte maturation31352102
802glyphosatefemale gamete generationincreaseoocyte maturationGO:0001556Homo sapiensglyphosate inhibits the reaction [CGA protein results in increased oocyte maturation]30266436
803Gossypolfemale gamete generationaffectmeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusGossypol affects meiotic cell cycle process involved in oocyte maturation34509492
804Gossypolfemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus[Gossypol affects meiotic cell cycle process involved in oocyte maturation] which results in decreased polar body extrusion after meiotic divisions34509492
805Gossypolfemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus[Gossypol affects meiotic cell cycle process involved in oocyte maturation] which results in decreased meiotic spindle organization34509492
806Gossypolfemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus[Gossypol affects meiotic cell cycle process involved in oocyte maturation] which results in decreased chromosome organization involved in meiotic cell cycle34509492
807Guaninefemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
808Heparinfemale gamete generationaffectoogenesisGO:0009790Mus musculusHeparin interrupts energy metabolism and meiotic progression and adversely affects subsequent development of oocytes under conditions of elevated cAMP levels in cumulus-oocyte complexes (COCs) after pre-IVM treatment with forskolin.23559189
809Heparinfemale gamete generationaffectoogenesisGO:0009790Mus musculusHeparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence23559189
810Heparinfemale gamete generationaffectoogenesisGO:0009790Homo sapiensHeparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence23559189

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.