Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
766
Doxorubicin
female gamete generation
increase
negative regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904145
Mus musculus
Doxorubicin results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation
31368505
767
Eicosapentaenoic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
768
Elaidic acid (C18:1n9t)
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
769
Endosulfan
female gamete generation
increase
oocyte maturation
GO:0001556
Homo sapiens
Endosulfan inhibits the reaction [CGA protein results in increased oocyte maturation]
30266436
770
EPA (C20:5n3)
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
771
Epitalon
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
Epitalon decreases the frequency of fragmentation in the post-ovulatory aged oocytes and during parthenogenetic activation
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
772
Erucic acid (C22:1n9)
female gamete generation
relate
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
773
Estradiol
female gamete generation
decrease
initiation of primordial ovarian follicle growth
GO:0001544
Mus musculus
Estradiol inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo.
17446182
774
Estriol
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
775
estrogens
female gamete generation
affect
oocyte development
GO:0048599
Mus musculus
Exposure of female mice to environmental estrogens can alter oocyte development, limiting the number of primordial follicles that can be used for reproduction.
22406039
776
Estrone
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
777
Etoposide
female gamete generation
affect
oocyte aneuploidy
N/A
Mus musculus
Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse
10029682
778
Etoposide
female gamete generation
affect
oocyte chromosomal aberrations
N/A
Mus musculus
Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse
10029682
779
Etoposide
female gamete generation
affect
male germ cell chromosomal mutation
N/A
Mus musculus
Numerical and structural chromosome aberrations induced by etoposide (VP16) during oocyte maturation of mice: transmission to one-cell zygotes and damage to dictyate oocytes.
8671760
780
Fatty acid
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
The mouse cumulus-oocyte complexes (COCs) exposed to lipid-rich follicular fluid during their maturation had increased oocyte lipid content, induction of endoplasmic reticulum stress markers, and impaired oocyte nuclear maturation.
22440252
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
