Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
826
Isoleucine
female gamete generation
relate
oogenesis
GO:0009790
Homo sapiens
Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of proline, lactate, leucine and isoleucine, and lower levels of glucose.
22365382
827
Isoniazid
female gamete generation
decrease
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Isoniazid results in decreased meiotic cell cycle process involved in oocyte maturation
33771660
828
Isoproturon
female gamete generation
increase
ovulation from ovarian follicle
GO:0001542
Homo sapiens
isoproturon inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle]
19368227
829
Ketoconazole
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
Amphotericin B induce resumption of meiosis and indicate that they are likely to cause an accumulation of meiosis activating sterols in the cell-enclosed oocytes (CEO), but ketoconazole blocks the production of Meiosis-activating sterol (MAS).
11026570
830
L-3-Phenyllactic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
831
Lactate
female gamete generation
affect
oogenesis
GO:0009790
Homo sapiens
While animal studies revealed that, compared with glucose and pyruvate, follicular cells did not particularly rely on lactate for their energy requirements, lactate may, however, have additional, non-metabolic roles in the acidification of the local environment.
34944731, 2081802
832
Lactate
female gamete generation
relate
oogenesis
GO:0009790
Homo sapiens
Oocytes which failed to cleave as an embryo had lower follicular fluid levels of lactate than embryos that implanted.
22365382
833
Lactate
female gamete generation
relate
oogenesis
GO:0009790
Homo sapiens
Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of lactate.
22365382
834
L-Aspartyl-L-phenylalanine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
835
L-Carnitine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
836
L-Carnitine
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
oocytes isolated from the follicles treated with l-carnitine had greater rates of maturity (metaphase II/MII), higher fertilization rates and improved blastocyst development
22917873, 21613630
837
Cysteine
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
838
L-Cystine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
839
L-Dihydroorotic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
840
L-Dopa
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
