Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
811
Hexadecanedioic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
812
High Fat Diet
female gamete generation
affect
chromosome alignment abnormalities
N/A
Mus musculus
Mice maintained on a high-fat diet produce oocytes with meiotic spindle and chromosome alignment abnormalities, which will lead to aneuploidy embryos.
23152876
813
Histamine
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
814
Hyodeoxycholic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
815
Hypotaurine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
816
Hypoxanthine
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Uridine had no effect on germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) when meiotic arrest was maintained with hypoxanthine or hypoxanthine plus adenosine but reversed the combined inhibitory action of these purines in denuded oocytes (DOs).
10331459
817
Hypoxanthine
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Uridine had no effect on germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) when meiotic arrest was maintained with hypoxanthine or hypoxanthine plus adenosine but reversed the combined inhibitory action of these purines in denuded oocytes (DOs).
10331459
818
Hypoxanthine l-1
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
AY9944-A-7 stimulated dose dependently (5-25 mumol l-1) COC to resume meiosis when cultured for 22 h in alpha minimal essential medium (alpha-MEM) containing 4 mmol hypoxanthine l-1, a natural inhibitor of meiotic maturation.
10793639
819
inosine
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Uptake and metabolism of adenosine mediate a meiosis-arresting action on mouse oocytes and inosine mimic the synergistic interaction of adenosine with hypoxanthine.
10331459
820
Inosinic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
821
Inositol
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Homo sapiens
[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation
26545973
822
Iodoacetate
female gamete generation
decrease
oocyte maturation
GO:0001556
Mus musculus
The iodoacetate-induced impairment of oocyte cytoplasmic maturation was not due to drug toxicity
26857840
823
Iprodione
female gamete generation
increase
oocyte maturation
GO:0001556
Homo sapiens
iprodione promotes the reaction [CGA protein results in increased oocyte maturation]
30266436
824
isobutylmethylxanthine (IBMX)
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
Isobutylmethylxanthine stimulated an increase
in oocyte maturation.
10331459
825
Isocitric acid
female gamete generation
not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
