Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
781
Folic Acid
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Homo sapiens
[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation
26545973
782
Fructose-6-phosphate
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
Fructose-6-phosphate (F-6-P) can overcome the inhibitory effect of DHEA on ooplasmic maturation
26857840
783
Fumaric acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
784
Gefitinib
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Gefitinib affects meiotic cell cycle process involved in oocyte maturation
33548356
785
Gefitinib
female gamete generation
decrease
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
[Gefitinib affects meiotic cell cycle process involved in oocyte maturation] which results in decreased meiotic prophase I
33548356
786
Genistein
female gamete generation
increase
oocyte maturation
GO:0001556
Homo sapiens
Genistein inhibits the reaction [CGA protein results in increased oocyte maturation]
30266436
787
Genistein
female gamete generation
decrease
initiation of primordial ovarian follicle growth
GO:0001544
Mus musculus
Genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo.
17446182
788
Gluconolactone
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
789
Glucose
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
By manipulating glucose metabolism pathways using a maturation medium that could support oocyte nuclear maturation but only a limited blastocyst formation without glucose.
26857840
790
Glucose
female gamete generation
relate
oogenesis
GO:0009790
Homo sapiens
Oocytes which failed to cleave as an embryo had higher follicular fluid levels of glucose.
22365382
791
Glucose
female gamete generation
relate
oogenesis
GO:0009790
Homo sapiens
Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have lower follicular fluid levels of glucose.
22365382
792
Glucose 6-phosphate
female gamete generation
relate
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
793
Glutamine
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
glutamine supports oocyte viability but is not an adequate energy source for the completion of spontaneous meiotic maturation and may be detrimental.
11108555
794
Glutathione
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
795
Glutathione
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Homo sapiens
[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation
26545973
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