Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
751
Diethylstilbestrol
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Mus musculus
[Diethylstilbestrol inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic anaphase I
29458137
752
Diethylstilbestrol
female gamete generation
affect
oocyte development
GO:0048599
Mus musculus
Estrogens can affect neonatal oocyte development. Exposure of neonates to estrogenic compounds such as estradiol (E2), phytoestrogens like genistein?or with synthetic estrogens including diethylstilbestrol (DES)?or bisphenol-A (BPA)?significantly increases the number of multiple oocyte follicles (MOFs) in ovaries of exposed animals when they are examined as adults.?The oocytes in a MOF are believed to be remnants of a germ cell cyst that did not properly separate and instead the oocytes became enclosed together in one follicle.
3764775, 2271729, 22406039
753
Dihydrotestosterone
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
754
Dihydroxyacetone phosphate
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
755
Diisobutyl phthalate
female gamete generation
decrease
oocyte development
GO:0048599
Mus musculus
[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development
28013214
756
Diisodecyl phthalate
female gamete generation
decrease
oocyte development
GO:0048599
Mus musculus
[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development
28013214
757
Diisodecyl phthalate
female gamete generation
decrease
oocyte maturation
GO:0001556
Homo sapiens
Diisodecyl phthalate results in decreased oocyte maturation
26545148
758
Dimethylformamide
female gamete generation
increase
negative regulation of oocyte maturation
GO:1900194
Mus musculus
Dimethylformamide results in increased negative regulation of oocyte maturation
35238128
759
Dimethylformamide
female gamete generation
increase
negative regulation of oocyte maturation
GO:1900194
Mus musculus
Melatonin inhibits the reaction [Dimethylformamide results in increased negative regulation of oocyte maturation]
35238128
760
Diuron
female gamete generation
increase
ovulation from ovarian follicle
GO:0001542
Homo sapiens
Diuron inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle]
19368227
761
Docosahexaenoic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
762
Dodecanedioic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
763
Dodecanoic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
764
Doxorubicin
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
Oocytes exposed to doxorubicin (DXR), a widely used chemotherapeutic agent, rapidly undergo morphological and biochemical changes via discrete effector signaling pathways consistent with the occurrence of apoptosis
16439991
765
Doxorubicin
female gamete generation
increase
negative regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904145
Mus musculus
Doxorubicin results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation
28329872
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
