Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
736Diazooxonorleucinefemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculusDiazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]29458137
737Diazooxonorleucinefemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculusDiazooxonorleucine inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II]29458137
738Diazooxonorleucinefemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculus[Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic prophase I29458137
739Diazooxonorleucinefemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculus[Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic metaphase I29458137
740Diazooxonorleucinefemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculus[Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic telophase I29458137
741Dibutyl Phthalatefemale gamete generationdecreaseoocyte developmentGO:0048599Mus musculus[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development28013214
742Dibutyryl cAMPfemale gamete generationincreaseoocyte maturationGO:0001556Mus musculusDibutyryl cAMP stimulated an increase in oocyte maturation.10331459
743Dietary fatsfemale gamete generationaffectmeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusThe first is oocyte meiotic aneuploidy that then leads to early embryonic loss. The second is an abnormal process distinct from meiotic aneuploidy that also leads to early embryonic loss. The third is fetal growth retardation and brain developmental abnormalities,23152876
744Dietary fatsfemale gamete generationaffectoocyte developmentGO:0048599Homo sapiensHigh fat diet induced metabolic abnormalities, resulting in developmental defects in human oocytes.
745Diethyl phthalatefemale gamete generationdecreaseoocyte developmentGO:0048599Mus musculus[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development28013214
746Diethylhexyl phthalatefemale gamete generationdecreaseoocyte developmentGO:0048599Mus musculus[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development28013214
747Diethylhexyl phthalatefemale gamete generationincreasepreantral ovarian follicle growthGO:0001546Mus musculusDiethylhexyl Phthalate results in increased preantral ovarian follicle growth28286118
748Diethylhexyl phthalatefemale gamete generationdecreaseoocyte maturationGO:0001556Homo sapiensDiethylhexyl Phthalate results in decreased oocyte maturation26545148
749Diethylstilbestrolfemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculusDiethylstilbestrol inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]29458137
750Diethylstilbestrolfemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculusDiethylstilbestrol inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II]29458137

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.