Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
61Alpha-ketoglutarateembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
62Alpha-ketoglutarateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
63Alpha-ketoisovaleric acidembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
64Alternariol (AOH) embryo developmentaffectembryo developmentGO:0009790Mus musculusAlternariol (AOH) and ochratoxin A (OTA), two mycotoxins found in many foods worldwide, exhibit cytotoxicity and embryotoxicity, triggering apoptosis and cell cycle arrest in several mammalian cells and mouse embryos. 34956623
65Amino Acidsembryo developmentaffectembryo developmentGO:0009790Mus musculusAmino Acids and Ammonium Regulate Mouse Embryo Development in Culture8439627
66Amino acidsembryo developmentaffecttrophectodermal cell differentiationGO:0001829Mus musculusExogenous Amino Acids Regulate Trophectoderm Differentiation in the Mouse Blastocyst through an mTOR-Dependent Pathway11784055
67Amino acidsembryo developmentaffectembryo implantationGO:0007566Mus musculusAmino Acid transport regulates blastocyst implantation12801981
68Amino-oxyacetateembryo developmentdecreaseembryo developmentGO:0009790Mus musculusAmino-oxyacetate (AOA), which inhibits the transamination of glutamate to a-ketoglutarate and therefore the metabolism of a substantial number of amino acids, was found to reduce the rates of blastocyst formation at concentrations above 0.5 mM.8868245
69Amitriptylineembryo developmentaffectembryo developmentGO:0009790Mus musculusExposure of mouse embryos in whole embryo culture to amitriptyline caused craniofacial malformations.1412065
70Ammoniumembryo developmentaffectembryo developmentGO:0009790Mus musculusAmmonium regulate mouse embryo development in culture8439627
71Ammoniumembryo developmentdecreaseblastocyst developmentGO:0001824Homo sapiensIncreased ammonium in culture medium may promote cellular apoptosis and negatively affect pluripotency of human blastocysts.36394664
72Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoateembryo developmentdecreaseembryonic placenta developmentGO:0001892Mus musculusAmmonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate affects embryonic placenta development32074459
73Ammonium chlorideembryo developmentdecreaseembryo developmentGO:0009790Mus musculusAmmonium has been shown to decrease embryo cleavage and blastocyst development, decrease blastocyst cell number, alter metabolism, and increase apoptosis16221986
74Ammonium chlorideembryo developmentdecreaseembryo developmentGO:0009790Mus musculusExposure to ammonium during the entire preimplantation stage, from the zygote to the blastocyst, also decreases implantation rates and fetal development as well as increasing the incidence of fetal abnormalities16221986
75AMPembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399

Showing 61 to 75 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.