Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
315-Azacytidineembryo developmentincreaseembryo developmentGO:0009790Homo sapiens It is a potent inducer of cardiomyogenic differentiation in adult stem cells.17979183?
325-Methylcytosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
336-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trolox)embryo developmentaffectembryo developmentGO:0009790Mus musculusCo-treatment with noncytotoxic concentrations of AgNPs (10 35782646
346MQTembryo developmentnotblastocyst developmentGO:0001824Mus musculusIn vitro fertilization (IVF) experiments using Swiss albino mice revealed that spermatozoa processed with 6MQT had non-significantly higher blastocyst rate and a superior blastocyst quality. (6MQT ((4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one))33237520
357-Methylguanosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
369-cis RA (9c-RA)embryo developmentincreaseembryo developmentGO:0009790Mus musculusincrease the number of cardiomyocytes during mouse ES cell differentiation 17979183?
37Acetyl phosphateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
38Acetylcarnitineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
39Acetylcarnitineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
40Acetylcarnitineembryo developmentincreaseembryo developmentGO:0009790Mus musculusthe antioxidant combination Acetyl-L-Carnitine, N-Acetyl-L-Cysteine and 29136144, 27165621
41Aconitic acidembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
42Actinomycin Dembryo developmentdecreaseembryo developmentGO:0009790Mus musculusMouse embryo is very sensitive to actinomycin D: at low concentrations the antibiotic blocks the development of the embryo in culture at early stages. The development of the embryos in culture was markedly depressed after continuous incubation with 0.01 and 0.1 563792, 5461023
43Adenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
44ADPembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
45ADPembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.