Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
91
Betaine
embryo development
affect
DNA methylation involved in embryo development
GO:0043045
Mus musculus
betaine can effectively rescue development of embryos harmed by ethanol, and possibly by restoring global level of genome DNA methylation in blastocysts.
29379082
92
Betaine
embryo development
affect
embryo development
GO:0009790
Mus musculus
Betaine (N,N,N-trimethylglycine) has previously been shown to function in cell volume homeostasis in early mouse embryos and also to be a key donor to the methyl pool in the blastocyst.
24599290, 11984829
93
Betaine aldehyde
embryo development
related
embryo development
GO:0009790
Mus musculus
Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC
36167681
94
Bexarotene
embryo development
decrease
embryonic morphogenesis
GO:0048598
Mus musculus
Bexarotene results in decreased embryonic morphogenesis
26385866
95
Bictegravir
embryo development
decrease
embryonic morphogenesis
GO:0048598
Mus musculus
bictegravir results in decreased embryonic morphogenesis
34515794
96
Biotin
embryo development
increase
embryo development
GO:0009790
Mus musculus
Significantly higher percentage of zygotes progressed to two-cell stage in both biotin (P?
30284103
97
Biotin
embryo development
related
embryo development
GO:0009790
Mus musculus
Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography
34428399
98
Bis(1,3-dichloropropyl)phosphate
embryo development
affect
embryonic placenta morphogenesis
GO:0060669
Homo sapiens
[Flame Retardants results in increased abundance of bis(1,3-dichloropropyl)phosphate] which affects embryonic placenta morphogenesis
33677611
99
bisphenol S
embryo development
decrease
embryonic cleavage
GO:0040016
Mus musculus
bis(4-hydroxyphenyl)sulfone results in decreased embryonic cleavage
33476676
100
Bisphenol A
embryo development
decrease
specification of segmental identity, mandibular segment
GO:0042305
Mus musculus
bisphenol A results in decreased specification of segmental identity, mandibular segment
31756439
101
Bisphenol A
embryo development
decrease
somite development
GO:0061053
Mus musculus
bisphenol A results in decreased somite development
31756439
102
Bisphenol A
embryo development
decrease
somite development
GO:0061053
Mus musculus
bisphenol A results in decreased somite development
31756439
103
Brilliant blue
embryo development
decrease
embryonic morphogenesis
GO:0048598
Mus musculus
brilliant blue results in decreased embryonic morphogenesis
28927898
104
Butylated hydroxyanisole
embryo development
decrease
embryonic morphogenesis
GO:0048598
Mus musculus
Butylated Hydroxyanisole results in decreased embryonic morphogenesis
28927898
105
Butylbenzyl phthalate
embryo development
decrease
embryo development
GO:0009790
Mus musculus
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased embryo development
33711355
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
