Chemicals with Transgenerational Effects on Disease or Function

Show
entries
No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
661Biotinfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
662bisphenol Sfemale gamete generationincreasenegative regulation of oocyte maturationGO:1900194Mus musculusbis(4-hydroxyphenyl)sulfone results in increased negative regulation of oocyte maturation33476676
663Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)]female gamete generationincreasefollicle developmentN/AMus musculusActivation of the PI3K-Akt-Foxo3 pathway in oocytes and increased follicle development after treatment with bpV(pic) and 740Y-P. 20479243
664Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)]female gamete generationincreasefollicle developmentN/AMus musculusActivation of dormant primordial follicles after in vitro treatment with bpV(pic) and 740Y-P.20479243
665Bisphenol Afemale gamete generationaffectmeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusbisphenol A results in decreased meiotic cell cycle process involved in oocyte maturation28178360
666Bisphenol Afemale gamete generationdecreaseovarian cumulus expansionGO:0001550Mus musculusbisphenol A results in decreased ovarian cumulus expansion29458137
667Bisphenol Afemale gamete generationdecreaseregulation of oocyte maturationGO:1900193Mus musculusbisphenol A affects regulation of oocyte maturation29458137
668Bisphenol Afemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculusbisphenol A inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]29458137
669Bisphenol Afemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculusbisphenol A inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II]29458137
670Bisphenol Afemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculus[bisphenol A inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic anaphase I29458137
671Bisphenol Afemale gamete generationincreasepositive regulation of meiotic cell cycle process involved in oocyte maturationGO:1904146Mus musculus[bisphenol A inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic telophase I29458137
672Bisphenol Afemale gamete generationincreasenegative regulation of oocyte maturationGO:1900194Mus musculusbisphenol A results in increased negative regulation of oocyte maturation29958887
673Bisphenol Afemale gamete generationdecreaseprimary ovarian follicle growth involved in double layer follicle stageGO:0043929Mus musculusbisphenol A results in decreased primary ovarian follicle growth involved in double layer follicle stage30675821
674Bisphenol Afemale gamete generationdecreasepreantral ovarian follicle growthGO:0001546Mus musculusbisphenol A results in decreased preantral ovarian follicle growth33718757
675Bisphenol Afemale gamete generationaffectoocyte developmentGO:0048599Mus musculusEstrogens can affect neonatal oocyte development. Exposure of neonates to estrogenic compounds such as estradiol (E2), phytoestrogens like genistein?or with synthetic estrogens including diethylstilbestrol (DES)?or bisphenol-A (BPA)?significantly increases the number of multiple oocyte follicles (MOFs) in ovaries of exposed animals when they are examined as adults.?The oocytes in a MOF are believed to be remnants of a germ cell cyst that did not properly separate and instead the oocytes became enclosed together in one follicle. 11955941, 22406039

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.