Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
691
Chlordecone
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
Increase in 8-oxo-G in embryonic oocytes after CD exposure ( the levels of 8-oxo-G, which is one of the most common lesions produced in DNA)
31084621
692
Chlordecone
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
Gestational exposure to CD reduces H3K4me3 and H4ac marks in adult oocytes
31084621
693
Chlordecone
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H7 acetylation after chlordecone exposure.
31084621
694
Chlordecone
female gamete generation
decrease
oogenesis
GO:0009790
Mus musculus
To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H6 acetylation after chlordecone exposure.
31084621
695
Chlordecone
female gamete generation
increase
oogenesis
GO:0009790
Mus musculus
To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H4 acetylation after chlordecone exposure.
31084621
696
Chlordecone
female gamete generation
increase
oogenesis
GO:0009790
Mus musculus
To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H5 acetylation after chlordecone exposure.
31084621
697
Chlorpropham
female gamete generation
increase
ovulation from ovarian follicle
GO:0001542
Homo sapiens
Chlorpropham inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle]
19368227
698
Cholest-5,24-diene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
11988327
699
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9603267, 11988327
700
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9788247, 11988327
701
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9788247, 11988327
702
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9788247, 11988327
703
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9788247, 9603267, 11988327
704
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9603267, 11988327
705
Cholest-5-ene-3
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period
9603267, 11988327
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
