Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
646
Alpha-ketoglutarate
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
647
Aminocaproic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
648
Amphotericin B
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
Amphotericin B induce resumption of meiosis and indicate that they are likely to cause an accumulation of meiosis activating sterols in the cell-enclosed oocytes (CEO), but ketoconazole blocks the production of Meiosis-activating sterol (MAS).
11026570
649
Arachidic acid (C20:0)
female gamete generation
relate
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
650
Arachidonic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
651
Arachidonic acid
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
GV oocytes cultured in medium supplemented with one of PUFAs, arachidonic acid (ARA), resulted in the meiotic defects and decreased accumulation of NFKB activating protein (NKAP).
35086109
652
Arachidonic acid (C20:4n6)
female gamete generation
relate
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
653
Argininosuccinic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
654
Ascorbic acid
female gamete generation
increase
positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904146
Homo sapiens
[Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation
26545973
655
Atrazine
female gamete generation
affect
ovulation from ovarian follicle
GO:0001542
Homo sapiens
Atrazine affects the reaction [CGB3 protein results in increased ovulation from ovarian follicle]
19368227
656
Atrazine
female gamete generation
increase
positive regulation of ovulation
GO:0060279
Homo sapiens
Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased positive regulation of ovulation]
26923738
657
AY9944-A-7
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
AY9944-A-7 induced a dose dependent resumption of oocyte meiosis in CEO in the presence of HX, but had no effect on NO.
11133661, 11988327, 10793639
658
Behenic acid (C22:0)
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
659
Beta-Alanine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
660
Betaine
female gamete generation
affect
oocyte maturation.
GO:0001556
Mus musculus
Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation.
28663368?
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