Chemicals with Transgenerational Effects on Disease or Function

Show
entries
No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
601phenylalanineembryo developmentrelatedembryo developmentGO:0009790Mus musculusOn day 5 of embryo culture in vitro, phenylalanine was depleted at significant rates.7799310
602(-)-Matairesinolfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
6031-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanonefemale gamete generationaffectmeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus[1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone results in decreased meiotic cell cycle process involved in oocyte maturation] which affects germinal vesicle35760214
6041-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanonefemale gamete generationdecreaseoocyte maturationGO:0001556Mus musculus[1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone affects meiotic cell cycle process] which results in decreased oocyte maturation35760214
6051-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanonefemale gamete generationdecreaseoocyte maturationGO:0001556Mus musculus1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone results in decreased oocyte maturation35760214
6061-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanonefemale gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculus1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone results in decreased meiotic cell cycle process involved in oocyte maturation35760214
6071-Palmitoyl-Palmitoylfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
6082,3',4,4',5-pentachlorobiphenylfemale gamete generationaffectoocyte maturationGO:0001556Mus musculusPrenatal exposure to 2,3',4,4',5-pentachlorobiphenyl disturbed the maturation process of progeny mouse oocytes in a dose-dependent manner.31388691
6092,3',4,4',5-pentachlorobiphenylfemale gamete generationaffectoocyte DNA methylationN/AMus musculusPrenatal exposure to 2,3',4,4',5-pentachlorobiphenyl altered the DNA methylation status of differentially methylated regions in some imprinted genes.31388691
6102-[p-carbonyl-ethyl)-phenylethylamino]-5female gamete generationnotmeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusA dose-response experiment was conducted to assess the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. A noinhibition group, composed of NECA and CGS21680, in which no augmentation of meiotic arrest was observed.10331459
6112-chloro-adenosinefemale gamete generationaffectmeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusa high-inhibition group, composed of adenosine, 2-Cl-Ado, and R-PIA, in which a low percentage of oocytes resumed maturation (010331459
6122-Furoic acidfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
6132-Hydroxypalmitic Acidfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
6143,4,5-Trimethoxycinnamic acidfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
6153'-AMPfemale gamete generationrelatedoogenesisGO:0048477Mus musculusSignificantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521

Showing 601 to 615 of 1481 entries

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.