Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
586XMPembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
587Y 27632embryo developmentdecreasepositive regulation of convergent extension involved in gastrulationGO:1904105Mus musculusY 27632 results in decreased positive regulation of convergent extension involved in gastrulation27693483
588Y 27633embryo developmentaffectembryo developmentGO:0009790Homo sapiensY27632 is one of optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells21266967
589Y 27634embryo developmentincreasepositive regulation of endodermal cell differentiationGO:1903226Homo sapiensY 27632 co-treated with BMP4 protein results in increased positive regulation of endodermal cell differentiation29143419
590Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusGestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K28 were elevated31058416
591Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusGestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K28 were elevated31058416
592Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusHistone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic25155023, 24810297
593Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusHistone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic25155023, 24810297
594Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusHistone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic25155023, 24810297
595Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusHistone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic25155023, 24810297
596Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusHistone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic25155023, 24810297
597Zearalenoneembryo developmentincreaseDNA methylation involved in embryo developmentGO:0043045Mus musculusThe fluorescence intensity analysis showed that 5-methyl cytosine level increased after ZEA treatment, indicating that the general DNA methylation level increased in the treated eggs. 25155023, 24810297
598Zearalenoneembryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusGestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K27 were elevated31058416, 31419471
599Zearalenoneembryo developmentrelatedDNA methylation involved in embryo developmentGO:0043045Mus musculusGestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The DNA methylation marker 5hmC was decreased.31058416, 31419471
600asparagineembryo developmentrelatedembryo developmentGO:0009790Mus musculusOn day 5 of embryo culture in vitro, asparagine was depleted at significant rates.7799310

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.