Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
571Valineembryo developmentrelatedembryo developmentGO:0009790Mus musculusOmission of lysine, methionine, phenylalanine, tryptophane and tyrosine from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely; while omission of isolecine and valine reduced the extent of outgrowth only slightly. Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
572Valine-Norvalineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
573Valine-Norvalineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
574Valproic acidembryo developmentdecreasepositive regulation of convergent extension involved in gastrulationGO:1904105Mus musculusValproic Acid results in decreased positive regulation of convergent extension involved in gastrulation27693483
575Valproic acidembryo developmentdecreaseembryo developmentGO:0009790Homo sapiensValproic acid reduced viability in human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB).34742744
576Valproic acidembryo developmentincreaseblastocyst developmentGO:0001824Mus musculusBoth the 2?mM VPA (38.3%) and the 100?nM TSA (34.5%) treatments resulted in a blastocyst development rate significantly higher than the obtained in the corresponding control group.20698782
577Verapamilembryo developmentincreaseembryo developmentGO:0009790Mus musculusL-type of Ca2+ channel blocker, verapamil have the most striking pro-cardiomyogenic effects in mouse ES cells. 17979183?
578Vitamin Aembryo developmentrelateembryo developmentGO:0009790Homo sapiensVitamin A is essential for normal diaphragm development, and it has been hypothesized that disruption of retinoid signaling may contribute to the etiology of the human disorder.12621107
579Vitamin B12embryo developmentaffectembryo developmentGO:0009790Homo sapiensMicronutrient (folate, B12, B6) deficiencies or insufficiency could influence fetal growth by their effect on folate/methionine metabolism in the mother and the fetus.?22418620
580Pyridoxineembryo developmentaffectembryo developmentGO:0009790Homo sapiensMicronutrient (folate, B12, B6) deficiencies or insufficiency could influence fetal growth by their effect on folate/methionine metabolism in the mother and the fetus.?22418620
581Ascorbic acidembryo developmentincreaseembryo developmentGO:0009790Homo sapiensAscorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes12668514, 17979183
582Xanthineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
583Xanthohumolembryo developmentaffectnegative regulation of heterotypic cell-cell adhesionGO:0034115Homo sapiensxanthohumol affects negative regulation of heterotypic cell-cell adhesion23503627
584Xanthosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
585Xanthosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276

Showing 571 to 585 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.