Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
466Retinoic acidembryo developmentincreaseembryo developmentGO:0009790Mus musculusLocal embryonic retinoic acid (RA) synthesis by Raldh2 is essential for early postimplantation mouse development.17979183?
467Retinoic acidembryo developmentaffectlimb developmentGO:0060173Mus musculusRetinoic acid act as a morphogenic substance in vertebrate limb development.1661245
468Retinoic acidembryo developmentincreaseheart morphogenesisGO:0003007Mus musculusRetinoic acid is required in the mouse embryo for left17979183?
469Retinoic acidembryo developmentaffectembryonic hindlimb morphogenesisGO:0035116Homo sapiensN/A1661245
470retinoidsembryo developmentaffectlimb developmentGO:0060173Mus musculusRetinoids act as a morphogenic substance in vertebrate limb development.1661245
471retinoidsembryo developmentaffectembryonic hindlimb morphogenesisGO:0035116Homo sapiensN/A1661245
472Vitamin Aembryo developmentaffectembryo developmentGO:0009790Homo sapienscongenital diaphragmatic hernia (CDH) is strongly associated with low retinol and RBP levels in newborns, independent of maternal retinol status. This is an important finding supporting the idea that human CDH is linked with abnormal retinoid homeostasis.20837596
473Rheinembryo developmentaffectembryo developmentGO:0009790Mus musculusRhein Induces oxidative stress and apoptosis in mouse blastocysts and has Immunotoxic effects during embryonic development28930172
474Rheinembryo developmentincreaseblastocyst developmentGO:0001824Mus musculusRhein Induces oxidative stress and apoptosis in mouse blastocysts and has Immunotoxic effects during embryonic development28930172
475Ribavirinembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusRibavirin results in decreased embryonic morphogenesis26385866
476Riboflavinembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
477Ribose 1,5-bisphosphateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
478Rotenoneembryo developmentdecreaseblastocyst growthGO:0001832Mus musculusDuring maturation of cumulus-oocyte-complexes (COCs) with pyruvate, electron transport inhibitor, rotenone or monocarboxylate transfer inhibitor, 4-CIN significantly decreased blastocyst rates. 26857840
479S-adenosylhomocysteineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
480S-adenosylhomocysteineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681

Showing 466 to 480 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.