Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
496S-methy-thioadenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
497Smokeembryo developmentincreaseneural tube developmentGO:0021915Homo sapiensCoal results in increased abundance of Smoke which results in increased abundance of Air Pollutants which results in decreased neural tube development24307569
498Sodium arsenateembryo developmentdecreaseneural crest cell fate specificationGO:0014036Mus musculussodium arsenite results in decreased neural crest cell fate specification26024302
499Sodium butyrateembryo developmentincreaseembryo developmentGO:0009790Mus musculusNaBu will promote the development of embryos in vitro.31356635
500Sodium fluorideembryo developmentdecreaseblastocyst formationGO:0001825Mus musculusSodium fluoride significantly reduced blastocyst formation during early embryonic development.25854509
501Sodium nitriteembryo developmentdecreaseembryonic cleavageGO:0040016Mus musculusSodium Nitrite results in decreased embryonic cleavage31476334
502Sodium nitroprussideembryo developmentdecreaseembryo developmentGO:0009790Mus musculussodium nitroprusside significantly decreased blastocyst formation during embryo development.25180787
503Spermidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
504Spermidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
505Sphingomyelinembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
506Sphingosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
507Sphingosine-1-Phosphateembryo developmentaffectembryo developmentGO:0009790Mus musculusSphingosine-1-Phosphate partly inhibits the effects of ceramide during preimplantation development of murine embryos.23731666
508Sphingosine-1-Phosphateembryo developmentaffectembryo developmentGO:0009790Homo sapiensAddition of S1P to human oocyte culture medium significantly reduced fertilization rate although such treatment decreased embryo fragmentation.20093086
509Sphingosyphosphocholineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
510Stauprimideembryo developmentaffectESC differentiationN/AMus musculusStauprimide increases the efficiency of definitive endoderm differentiation. They identified a small molecule, named stauprimide, that increases the efficiency of the directed differentiation of mouse and human ESCs in synergy with defined extracellular signaling cues. 19427291, 19896224

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.