Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
451Pyruvateembryo developmentrelateembryo developmentGO:0009790Homo sapiensThe IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization).18842260
452Pyruvateembryo developmentrelateembryo developmentGO:0009790Homo sapiensPyruvate and glucose uptakes on day 4 were significantly higher by embryos that went on to form blastocysts than by embryos that failed to develop to the blastocyst stage. Glucose uptakes were greatest in those blastocysts of highest grade, whereas pyruvate uptakes were similar irrespective of blastocyst grade, indicating that glucose is the more important nutrient for the human blastocyst.11730746
453Pyruvateembryo developmentrelateembryo developmentGO:0009790Homo sapiensNon-invasive microanalytical methods have been devised to study the energy metabolism of single human preimplantation embryos. Pyruvate, which is added routinely to all media used to culture human embryos, is consumed throughout the preimplantation period.8517855
454Pyruvic acidembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
455pyruvic acidembryo developmentaffectembryo developmentGO:0009790Mus musculuspyruvic acid is essential for initiating ZGA and selective translocation of key mitochondrial tricarboxylic acid (TCA) cycle proteins to the nucleus?28086092
456quercetinembryo developmentincreaseembryo developmentGO:0009790Mus musculusTreating oocytes from aged mice with quercetin improves early embryonic development33177495
457quercetinembryo developmentincreaseembryo developmentGO:0009790Homo sapiensQuercetin improves human oocyte early embryonic development.33177495
458quinalphosembryo developmentdecreaseblastocyst developmentGO:0001824Mus musculusquinalphos results in decreased blastocyst development34014595
459Raloxifene Hydrochlorideembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusRaloxifene Hydrochloride results in decreased embryonic morphogenesis26385866
460Raltegravir Potassiumembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusRaltegravir Potassium results in decreased embryonic morphogenesis34515794
461ramelteonembryo developmentaffectregulation of gastrulationGO:0010470Mus musculusramelteon affects regulation of gastrulation28184906
462Rapamycinembryo developmentaffecttrophectodermal cell differentiationGO:0001829Mus musculusRapamycin, a specific inhibitor of the kinase mTOR/FRAP/RAFT1, blocks amino acid stimulation of embryo outgrowth, demonstrating that mTOR is required for the initiation of trophectoderm protrusive activity.11784055
463Repaglinideembryo developmentaffectembryonic cleavageGO:0040016Mus musculusRepaglinide can be considered as an effective agent for in vitro embryo cleavage.28432599
464Resveratrolembryo developmentincreaseblastocyst formationGO:0001825Mus musculusResveratrol induced blastocyst formation in aged mice.29778389
465Resveratrolembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusResveratrol results in decreased embryonic morphogenesis29990529

Showing 451 to 465 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.