Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
481S-Adenosyl-methionineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
482S-Adenosyl-methionineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
483Salicylic Acidembryo developmentaffectregulation of gastrulationGO:0010470Mus musculusSalicylic Acid affects regulation of gastrulation28184906
484SB431542embryo developmentaffectESC differentiationN/AHomo sapiensThe synergistic action of two inhibitors of SMAD signaling, Noggin and SB431542, is sufficient to induce rapid and complete neural conversion of >80% of hES cells under adherent culture conditions. 19252484, 19896224
485SDMA-ADMAembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
486SDMA-ADMAembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
487Sedoheptulose 7-phosphateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
488Serineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
489Serotonin?embryo developmentaffectheart morphogenesisGO:0003007Mus musculusSerotonin?(5-HT) may play a role in cardiac morphogenesis during endocardial cushion formation.8367830, 3209688
490Sertralineembryo developmentaffectembryo developmentGO:0009790Mus musculusExposure of mouse embryos in whole embryo culture to sertraline caused craniofacial malformations.1412065
491Silver nanoparticles (AgNPs)embryo developmentaffectembryo developmentGO:0009790Mus musculusCo-treatment with noncytotoxic concentrations of AgNPs (10 35782646
492Sirtinolembryo developmentdecreaseembryonic limb morphogenesisGO:0030326Mus musculussirtinol results in decreased embryonic limb morphogenesis26251326
4935'-Methylthioadenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
4945'-Methylthioadenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
495S-Methylmethionineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.