Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
421perfluorooctanoic acidembryo developmentaffectembryonic placenta developmentGO:0001892Mus musculusperfluorooctanoic acid affects embryonic placenta development32074459
422perfluorooctane sulfonateembryo developmentaffectDNA methylation involved in embryo developmentGO:0043045Homo sapiens[Environmental Pollutants results in increased abundance of perfluoroundecanoic acid] which affects DNA methylation involved in embryo development32653021
423Pesticidesembryo developmentaffectDNA methylation involved in embryo developmentGO:0043045Homo sapiens[[Environmental Pollutants results in increased abundance of Pesticides] which results in increased abundance of nonachlor] which affects DNA methylation involved in embryo development32653021
424Pesticidesembryo developmentincreasechanges to DNA methylation involved in embryo developmentGO:1901538Homo sapiens[[[Environmental Pollutants results in increased abundance of Pesticides] which affects changes to DNA methylation involved in embryo development] which affects genomic imprinting] which results in increased methylation of IGF2 gene30005188
425Pesticidesembryo developmentincreasechanges to DNA methylation involved in embryo developmentGO:1901538Homo sapiens[[[Environmental Pollutants results in increased abundance of Pesticides] which affects changes to DNA methylation involved in embryo development] which affects genomic imprinting] which results in decreased methylation of H19 gene30005188
426Phenylalanineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
427Phenylalanineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
428phenylalanineembryo developmentrelatedembryo developmentGO:0009790Mus musculusOmission of lysine, methionine, phenylalanine, tryptophane and tyrosine from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely; while omission of isolecine and valine reduced the extent of outgrowth only slightly. Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
429Phosphocholineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
430Phosphocholine embryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
431Phthalic Acidsembryo developmentdecreaseembryonic hindlimb morphogenesisGO:0035116Homo sapiens[Phthalic Acids results in increased abundance of diethyl phthalate] which results in decreased embryonic hindlimb morphogenesis24503621
432Phthalic Acidsembryo developmentdecreaseembryonic hindlimb morphogenesisGO:0035116Homo sapiens[Phthalic Acids results in increased abundance of Dibutyl Phthalate] which results in decreased embryonic hindlimb morphogenesis24503621
433Phthalic Acidsembryo developmentdecreaseembryonic hindlimb morphogenesisGO:0035116Homo sapiens[Phthalic Acids results in increased abundance of Diethylhexyl Phthalate] which results in decreased embryonic hindlimb morphogenesis24503621
434Pluripotin(SC1)embryo developmentaffectembryo developmentGO:0009790Mus musculusLong-term SC1-expanded murine ES cells can be differentiated into cells of the three primary germ layers in vitro and also can generate chimeric mice and contribute to the germ line in vivo. 17088537
435procyanidin B2embryo developmentaffectembryo developmentGO:0009790Mus musculusAntioxidant procyanidin B2 improves embryo development after vitrification35971139

Showing 421 to 435 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.