Chemicals with Transgenerational Effects on Disease or Function

Show
entries
No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
391octanoateembryo developmentincreaseblastocyst hatchingGO:0001835Mus musculusOctanoate supplementationin in embryo culture media allowed a successful rate of blastocyst hatching.23226596
392octanoic acidembryo developmentdecreaseembryo developmentGO:0009790Mus musculusOctanoic acid, a standard additive to human protein supplements used in IVF, can have long-term negative effects on embryonic and fetal development. 26342329
393octanoic acidembryo developmentdecreaseblastocyst developmentGO:0001824Mus musculus Octanoic acid reduces blastocyst development in a mouse embryo assay at concentrations that are clinically relevant Variability in protein quality used for embryo culture: embryotoxicity of the stabilizer octanoic acid. Fertil Steril. 2013;100:544
394oleic acidembryo developmentdecreaseembryo developmentGO:0009790Mus musculus?PA exerts a negative effect on mouse two-cell progression to the blastocyst stage, whereas oleic acid co-treatment reverses that negative effect.35038315
395oleic acidembryo developmentincreaseblastocyst formationGO:0001825 Mus musculusExogenous oleic and palmitic acids promoted blastocyst formation and hatching when added to 8-cell embryos.32542540
396organic pollutantsembryo developmentrelateDNA methylation involved in embryo developmentGO:0043045Homo sapiensDNA methylation changes in the placenta were significantly associated with maternal plasma Persistent organic pollutants (POPs) concentration. 32653021
397Ornithineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
398Oxaloacetateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
399Oxytocin embryo developmentincreasegrowth involved in heart morphogenesisGO:0003241Mus musculusOxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes15023550
400Palmitic acidembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
401palmitic acidsembryo developmentdecreaseembryo developmentGO:0009790Mus musculusPalmitic acid and PUFAs including linoleic acid inhibited the embryo development. The inhibitory effect of PUFAs was attenuated by adding antioxidants into the media, while the inhibitory effect of palmitic acid was not. 7633171
402palmitic acidsembryo developmentdecreaseembryo developmentGO:0009790Mus musculusthe number of inner cell mass (ICM) cells in mouse blastocysts was reduced, apoptosis of trophoblast stem cells increased, and proliferation decreased following addition of palmitate.21653893
403palmitic acidsembryo developmentdecreaseembryo developmentGO:0009790Mus musculusfetuses developing from palmitic acid-treated blastocysts were growth restricted but the offspring eventually outgrew the offspring from control blastocysts21653893
404palmitic acidsembryo developmentdecreaseembryo developmentGO:0009790Mus musculus palmitic acids exerts a negative effect on mouse two-cell progression to the blastocyst stage, whereas OA co-treatment reverses that negative effect.35038315
405palmitic acidsembryo developmentincreaseblastocyst hatchingGO:0001835Mus musculusExogenous oleic and palmitic acids promoted blastocyst formation and hatching when added to 8-cell embryos.32542540

Showing 391 to 405 of 1481 entries

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.