Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
346Methyl mercury(MeHg) embryo developmentaffectembryo developmentGO:0009790Mus musculusCo-treatment with noncytotoxic concentrations of AgNPs (10 35782646
347Methyl mercury(MeHg) embryo developmentaffectembryo developmentGO:0009790Mus musculusLow-dose silver nanoparticles plus methyl mercury exert embryotoxic effects on mouse blastocysts via endoplasmic reticulum stress and mitochondrial apoptosis35782646
348Methyl palmoxirateembryo developmentdecreaseembryo developmentGO:0009790Mus musculus Embryo development was reduced in the presence of 0.5, 1.0,and 10.0mM MP after 96 hr post-hCG and in the presence of 2.0 mM MP after 120 hr post-hCG. Cell numbers of blastocysts incubated in 10 mM MP were decreased by 26% compared to the controls8868245
349Methylmercuric chlorideembryo developmentaffectregulation of gastrulationGO:0010470Mus musculusmethylmercuric chloride affects regulation of gastrulation28184906
350Methylparabenembryo developmentaffectembryonic morphogenesisGO:0048598Mus musculusmethylparaben affects embryonic morphogenesis28927898
351Mifepristoneembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusMifepristone results in decreased embryonic morphogenesis26385866
352Mono-(2-ethylhexyl)phthalateembryo developmentaffectregulation of gastrulationGO:0010470Mus musculusmono-(2-ethylhexyl)phthalate affects regulation of gastrulation28184906
353Mono-(2-ethylhexyl)phthalateembryo developmentaffectcell differentiation involved in embryonic placenta developmentGO:0060706Homo sapiensmono-(2-ethylhexyl)phthalate affects cell differentiation involved in embryonic placenta development30810372
354Monomethylarsonous acidembryo developmentdecreaseneural crest cell fate specificationGO:0014036Mus musculusmonomethylarsonous acid results in decreased neural crest cell fate specification26024302
355MS-444embryo developmentdecreaseembryo developmentGO:0009790Mus musculusMS-444 arrested embryonic development at 2-cell stage36085230
356MS-444embryo developmentdecreaseembryo developmentGO:0009790Mus musculusMS-444 blocked the nucleocytoplasmic transport of Agbl2 mRNA by inhibiting HuR dimerization, resulting in arrest of embryonic development at the 2-cell phase. 36085230
357Mycophenolic acidembryo developmentdecreaseembryo developmentGO:0009790Homo sapiensin vitro in the cumulus-enclosed oocytes treated with IMPDH inhibitor mycophenolic acid (MPA). Inhibition of IMPDH activity in oocytes and preimplantation embryos compromises developmental competences and the development of embryos beyond the 4-cell stage,34124077
358Mycotoxin citrininembryo developmentaffectembryo developmentGO:0009790Mus musculusThe mycotoxin citrinin (CTN), a natural contaminant in foodstuffs and animal feeds, exerts cytotoxic and genotoxic effects on various mammalian cells and embryos. A previous investigation by our group revealed potentially hazardous effects of CTN on mouse oocyte maturation and pre- and post-implantation embryo development via the induction of apoptosis.29186930
359N,N-Dimethylglycineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
360n-3 PUFAembryo developmentaffectblastocyst developmentGO:0001824Mus musculusExposure of oocytes to an environment high in n-3 PUFA during in vivo fertilization decreased developmental ability to the blastocyst stage. 18073322

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.