Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
316leucineembryo developmentaffectchorionic trophoblast cell developmentGO:0060719Mus musculusLeucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo.22056783
317Leucineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
318Leucineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
319Leucineembryo developmentrelatedembryo developmentGO:0009790Mus musculusLeucine appeared to be the key amino acids sought by embryos on both days tested and embryos grown in amino-acid-containing media appeared morphologically normal and their volume increased compared with embryos cultured in the absence of amino acids.7799310
320Leucineembryo developmentaffectchorionic trophoblast cell proliferationGO:0097360Mus musculusLeucine are necessary and sufficient for trophoblast outgrowth.22056783, 36430764
321Leucineembryo developmentrelateembryo developmentGO:0009790Homo sapiensThe IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization).18842260
322Linoleic acidembryo developmentdecreaseembryo developmentGO:0009790Mus musculusPalmitic acid and PUFAs including linoleic acid inhibited the embryo development. The inhibitory effect of PUFAs was attenuated by adding antioxidants into the media, while the inhibitory effect of palmitic acid was not. 7633171
323Linoleic acidembryo developmentrelateembryo developmentGO:0009790Homo sapiensPreimplantation human embryos actively take up individual fatty acids at different rates at different stages of development. The high unsaturated concentration at the later stages of development may be explained by preferential uptake of linoleic acid.16311299
324Lipidembryo developmentrelatedembryo developmentGO:0009790Mus musculusThere is strong evidence for the utilization of endogenous lipid as an energy substrate by oocytes and early embryos.19660080
325liquiritigeninembryo developmentaffectembryo developmentGO:0009790Mus musculusPrevention of ochratoxin A-induced oxidative stress-mediated apoptotic processes and impairment of embryonic development in mouse blastocysts by liquiritigenin30698892, 29186930
326L-Pipecolic Acidembryo developmentincreaseblastocyst formationGO:0001825Mus musculusEmbryos fertilised in medium with proline and its homologue pipecolic acid showed increased blastocyst formation and inner cell mass cell numbers compared to embryos fertilised in medium containing no amino acids, betaine, glycine, or histidine.?34072568
327L-Prolineembryo developmentincreaseblastocyst formationGO:0001825Mus musculusEmbryos fertilised in medium with proline and its homologue pipecolic acid showed increased blastocyst formation and inner cell mass cell numbers compared to embryos fertilised in medium containing no amino acids, betaine, glycine, or histidine.?34072568
328Lysineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
329Lysineembryo developmentrelatedembryo developmentGO:0009790Mus musculusOmission of lysine, methionine, phenylalanine, tryptophane and tyrosine from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely; while omission of isolecine and valine reduced the extent of outgrowth only slightly. Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
330Lysophosphatidic acidembryo developmentaffectembryo developmentGO:0009790Mus musculusThe blastocyst rates from 2-cell and 4-cell stage embryos were significantly higher in the presence of lysophosphatidic acid (LPA) at the pronuclear stage. However, the blastocyst rate from 4-cell stage embryos was significantly lower when LPA was added to the medium at the 4-cell stage than when it was added at the pronuclear stage.8076690

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.