Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
301Isolecineembryo developmentrelatedembryo developmentGO:0009790Mus musculusOmission of lysine, methionine, phenylalanine, tryptophane and tyrosine from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely; while omission of isolecine and valine reduced the extent of outgrowth only slightly. Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
302Isolecineembryo developmentaffectembryo developmentGO:0009790Mus musculusIsoleucine appeared to be the key amino acids sought by embryos on both days tested and embryos grown in amino-acid-containing media appeared morphologically normal and their volume increased compared with embryos cultured in the absence of amino acids.7799310
303Isoleucineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
304Isoleucineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
305Isoleucineembryo developmentrelateembryo developmentGO:0009790Homo sapiensThe IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization).18842260
306Isoniazidembryo developmentdecreaseblastocyst developmentGO:0001824Mus musculusIsoniazid results in decreased blastocyst development33771660
307Kynurenineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
308L-2-hydroxyglutarate (L-2-HG)embryo developmentaffectchanges to DNA methylation involved in embryo developmentGO:1901538Mus musculusA decrease of L-2-HG facilitates global erasure of histone methylation during early embryo development.34650276
309Lactateembryo developmentaffectembryo developmentGO:0009790Mus musculusLactate and pyruvate together are able to support normal development of 1-cell F2 embryos to the morula stage in vitro.1769345
310Lactateembryo developmentaffectembryo developmentGO:0009790Mus musculusLactate supplementation activated germline genes in mouse embryonic stem cells (ESCs). 35159357
311Lactateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
312Lactateembryo developmentrelateembryo developmentGO:0009790Homo sapiensThe IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization).18842260
313Lactic acidembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
314Cysteineembryo developmentnotembryo developmentGO:0009790Mus musculus L-cysteine (L-Cys), D-cysteine (D-Cys) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo. 25715791
315leucineembryo developmentaffectblastocyst growthGO:0001832Mus musculusThe effect of glucose-, arginine- and leucine-deprivation on mouse blastocyst outgrowth in vitro442281

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.