Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
286Hydroxyprogesteroneembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
287Hydroxyprolineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
288Hydroxyureaembryo developmentaffectregulation of gastrulationGO:0010470Mus musculusHydroxyurea affects regulation of gastrulation28184906
289Hydroxyureaembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusHydroxyurea results in decreased embryonic morphogenesis29990529
290Hypoxanthineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
291Hypoxanthineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
292IDE1 (2-[6-carboxy-hexanoyl)-hydrazonomethyl]-benzoic acid)embryo developmentaffectendoderm formationGO:0001706Mus musculusTwo small molecules, IDE1 and IDE3, that can efficiently induce definitive endoderm (IDE) from mouse and human ESCs.19341624
293IDE1 (2-[6-carboxy-hexanoyl)-hydrazonomethyl]-benzoic acid)embryo developmentaffectendoderm formationGO:0001706Homo sapiensTwo small molecules, IDE1 and IDE2, that can efficiently induce definitive endoderm (IDE) from mouse and human ESCs.19341624
294IDE2 (7-(2-cyclopentylidenehydrazino)-7-oxoheptanoic acid)embryo developmentaffectendoderm formationGO:0001706Mus musculusTwo small molecules, IDE1 and IDE2, that can efficiently induce definitive endoderm (IDE) from mouse and human ESCs.19341624
295IDE2 (7-(2-cyclopentylidenehydrazino)-7-oxoheptanoic acid)embryo developmentaffectendoderm formationGO:0001706Homo sapiensTwo small molecules, IDE1 and IDE2, that can efficiently induce definitive endoderm (IDE) from mouse and human ESCs.19341624
296Inosinic acidembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
297Inosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
298Inosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
299Iodoacetateembryo developmentdecreaseblastocyst growthGO:0001832Mus musculusDuring maturation of cumulus-oocyte-complexes (COCs) with glucose, the presence of PPP inhibitor, DHEA or glycolysis inhibitor, iodoacetate significantly decreased blastocyst rates, intraoocyte glutathione and ATP. 26857840
300Ionomycinembryo developmentnotembryo developmentGO:0009790Mus musculusNo adverse effects of ionomycin on in-vitro or in-vivo mouse embryo development were noticed.19079959

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.