Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
271GMPembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
272GMPembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
273Glutathioneembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
274Glutathioneembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
275GSSGembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
276GSSGembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
277Guanosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
278Guanosineembryo developmentaffectembryo developmentGO:0009790Homo sapiensIn cultured cumulus-oocyte complexes (COCs) , mycophenolic acid-treatment causes the simultaneous formation of IMPDH cytoopidium in cumulus cells and the resumption of meiosis in oocytes, which is prevented by guanosine supplementation. 34124077
279GW 1929embryo developmentincreasecell differentiation involved in embryonic placenta developmentGO:0060706Homo sapiensGW 1929 results in increased cell differentiation involved in embryonic placenta development30810372
280Halogenated Diphenyl Ethersembryo developmentaffectDNA methylation involved in embryo developmentGO:0043045Homo sapiens[[Environmental Pollutants results in increased abundance of Halogenated Diphenyl Ethers] which results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which affects DNA methylation involved in embryo development32653021
281HhAntag691embryo developmentdecreasepositive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningGO:1901622Mus musculusHhAntag691 results in decreased positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning27585885
282High Fat Dietembryo developmentaffectaneuploidy embryoN/AMus musculusMice maintained on a high-fat diet produce oocytes with meiotic spindle and chromosome alignment abnormalities, which will lead to aneuploidy embryos. 23152876
283Histidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
284Histidineembryo developmentaffectembryo developmentGO:0009790Mus musculusArginine, cystine, histidine, leucine and threonine were needed for outgrowth of the mouse blastocyst in vitro.Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
285Homomethionineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681

Showing 271 to 285 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.